| Company Name: |
Abydos Scientific |
| Tel: |
18936879710 18851749494 |
| Email: |
sales@abydoscientific.com |
DuocarMycin TM manufacturers
- Duocarmycin TM
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2021-09-16
- CAS:157922-77-5
- Min. Order: 5mg
- Purity: 99%
- Supply Ability: 100KG
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| | DuocarMycin TM Basic information |
| Product Name: | DuocarMycin TM | | Synonyms: | DuocarMycin TM;CS-1380;1H-Benz[e]indol-5-ol, 1-(chloromethyl)-2,3-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, (1S)-;DNA Alkylator/Crosslinker,alkylation,Duocarmycin TM,Inhibitor,ADC Cytotoxin,BJAB cell,inhibit,Antibiotic,duplex DNA,CBI-TMI,Antitumor,ADC Payload,WSU-DLCL2 cell;Duocarmycin TM, 10 mM in DMSO;(1S)-1-(Chloromethyl)-2,3-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1H-benz[e]indol-5-ol | | CAS: | 157922-77-5 | | MF: | C25H23ClN2O5 | | MW: | 466.91 | | EINECS: | | | Product Categories: | | | Mol File: | 157922-77-5.mol |  |
| | DuocarMycin TM Chemical Properties |
| Boiling point | 711.7±60.0 °C(Predicted) | | density | 1.389±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 50 mg/mL (107.09 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 9.43±0.40(Predicted) | | color | Light yellow to yellow |
| | DuocarMycin TM Usage And Synthesis |
| Uses | Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA. | | IC 50 | Duocarmycins | | References | [1] Zhang D, et, al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274. DOI:10.1021/acs.bioconjchem.7b00576 |
| | DuocarMycin TM Preparation Products And Raw materials |
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