|
|
| | Sterculic acid Basic information |
| Product Name: | Sterculic acid | | Synonyms: | 8-(2-Octacyclopropen-1-yl)octanoic acid;8-(2 OCTYL 1-CYCLOPROPENYL) OCTANOIC ACID;STERCULIC ACID;9,10-Methylene-9-octadecenoicacid;2-Octyl-1-cyclopropene-1-octanoic acid;8-(2-octylcyclopropen-1-yl)caprylic acid;8-(2-octylcyclopropen-1-yl)octanoic acid;1-Cyclopropene-1-octanoic acid, 2-octyl- | | CAS: | 738-87-4 | | MF: | C19H34O2 | | MW: | 294.47 | | EINECS: | | | Product Categories: | | | Mol File: | 738-87-4.mol |  |
| | Sterculic acid Chemical Properties |
| Melting point | 19 °C | | Boiling point | 418.7±24.0 °C(Predicted) | | density | 0.948±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: soluble; Ether: soluble; Hexane: soluble; Methanol: soluble | | form | A liquid | | pka | 4.78±0.10(Predicted) | | color | Colorless to light yellow |
| | Sterculic acid Usage And Synthesis |
| Uses | Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM[1]. | | Definition | ChEBI: A long-chain, monounsaturated fatty acid composed of 9-octadecenoic acid having a 9,10-cyclopropenyl group. | | in vivo | Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1)
in vivo[3]. | | IC 50 | delta-9 desaturase: 0.9 μM (IC50) | | References | [1] Lei Zhang, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76. DOI:10.1177/1087057109356208
[2] Rafael Peláez, et al. Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. Cells. 2020 Jan 7;9(1):140. DOI:10.3390/cells9010140
[3] Abril Ramírez-Higuera, et al. Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model. J Med Food. 2020 Mar;23(3):305-311. DOI:10.1089/jmf.2019.0177 |
| | Sterculic acid Preparation Products And Raw materials |
|