| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
|
| | LY 456236 Basic information |
| | LY 456236 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: soluble2mg/mL, clear (warmed) | | form | powder | | color | white to beige |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 |
| | LY 456236 Usage And Synthesis |
| Uses | LY 456236 is a mGlu1 receptor antagonists, which may be used in the treatment of chronic pain and epilepsy and other seizure disorders. | | in vivo | LY456236 shows anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once)[3]. | Animal Model: | DBA/2 mice and CD1 mice, seizure models[3] | | Dosage: | 3-100 mg/kg | | Administration: | IP, once | | Result: | Produced dose-related anticonvulsant effects in preventing audiogenic-induced (tonic-clonic) seizures in DBA/2 mice, threshold electroshock-induced seizures in CD1 mice, and 6 Hz electroshock-induced seizures in CD1 mice. |
| Animal Model: | Amygdala-kindled Sprague-Dawley rats[3] | | Dosage: | 10, 30 and 60 mg/kg | | Administration: | Oral, once | | Result: | Produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. Produced a dose-related increase in the stimulus intensity required to produce generalized seizures. |
| | storage | Desiccate at RT |
| | LY 456236 Preparation Products And Raw materials |
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