LY 334370 hydrochloride

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Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
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LY 334370 hydrochloride manufacturers

  • LY334370
  • LY334370 pictures
  • $41.00
  • 2026-07-15
  • CAS:182563-08-2
  • Purity: 99.32%
  • Supply Ability: 10g
LY 334370 hydrochloride Basic information
Product Name:LY 334370 hydrochloride
Synonyms:4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamidehydrochloride;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide;BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-;4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate;LY-334370 hydrochloride hydrate;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride;LY 334370;4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-5-yl]-benzamide
CAS:182563-08-2
MF:C21H22FN3O
MW:351.42
EINECS:
Product Categories:
Mol File:182563-08-2.mol
LY 334370 hydrochloride Structure
LY 334370 hydrochloride Chemical Properties
Boiling point 479.1±45.0 °C(Predicted)
density 1.267±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility H2O: ≥5mg/mL (warmed)
form powder
pka13.98±0.43(Predicted)
color white to tan
Safety Information
WGK Germany 3
MSDS Information
LY 334370 hydrochloride Usage And Synthesis
UsesLY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.
Biological ActivitySelective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.
in vivo

Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actual dural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg)[1].

IC 505-HT1F Receptor: 1.6 nM (Ki)
LY 334370 hydrochloride Preparation Products And Raw materials
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