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| | (Deamino-Cys1,beta-cyclohexyl-Ala4,Arg8)-vasopressin Basic information |
| Product Name: | (Deamino-Cys1,beta-cyclohexyl-Ala4,Arg8)-vasopressin | | Synonyms: | (DeaMino-Cys1,Cha4,Arg8)-Vasopressin;3-Mercaptopropionyl-Tyr-Phe-b-cyclohexyl-Ala-Asn-Cys-Pro-Arg-Gly-NH2;3-MERCAPTOPROPIONYL-TYR-PHE-BETA-CYCLOHEXYL-ALA-ASN-CYS-PRO-ARG-GLY-NH2;3-MERCAPTOPROPIONYL-TYR-PHE-BETA-CYCLOHEXYL-ALA-ASN-CYS-PRO-ARG-GLY-NH2, (DISULFIDE BOND);(DeaMino-Cys1,b-cyclohexyl-Ala4,Arg8)-Vasopressin;(Deamino-Cys1,β-cyclohexyl-Ala?,Arg?)-Vasopressin;(Deamino-Cys1,b-cyclohexyl-Ala4,Arg8)-Vasopressin trifluoroacetate salt;Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-3-cyclohexyl-L-alanyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginyl-, cyclic (1→5)-disulfide | | CAS: | 500170-27-4 | | MF: | C50H71N13O11S2 | | MW: | 1094.31 | | EINECS: | | | Product Categories: | | | Mol File: | 500170-27-4.mol |  |
| | (Deamino-Cys1,beta-cyclohexyl-Ala4,Arg8)-vasopressin Chemical Properties |
| storage temp. | Store at RT | | form | Solid | | color | White to off-white | | Water Solubility | Soluble to 1 mg/ml in Water | | Sequence | {Mpa}-Tyr-Phe-{Cha}-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge:Mpa1-Cys6) |
| | (Deamino-Cys1,beta-cyclohexyl-Ala4,Arg8)-vasopressin Usage And Synthesis |
| Uses | d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2]. | | References | [1] Ling Ling Cheng, et al. Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88. DOI:10.1021/jm030611c
[2] Cristiana Griffante, et al. Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist. Br J Pharmacol. 2005 Nov;146(5):744-51. DOI:10.1038/sj.bjp.0706383 |
| | (Deamino-Cys1,beta-cyclohexyl-Ala4,Arg8)-vasopressin Preparation Products And Raw materials |
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