H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH
| 中文名称 | H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH |
|---|---|
| 中文同义词 | H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH;CALP3 三氟乙酸盐;钙样肽3Calcium-like peptide 3;钙样肽3 |
| 英文名称 | CALP3 |
| 英文同义词 | CALP3;Calcium-like peptide 3;Calcium-Like Peptide 3,CALP-3;Calcium-Like Peptide 3 trifluoroacetate salt H-Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-OH trifluoroacetate salt;L-Lysine, L-valyl-L-lysyl-L-phenylalanylglycyl-L-valylglycyl-L-phenylalanyl-;CALP3 - Calcium like peptide 3 |
| CAS号 | 261969-05-5 |
| 分子式 | C44H68N10O9 |
| 分子量 | 881.07 |
| EINECS号 | |
| 相关类别 | 标准品;Calcium signaling |
| Mol文件 | 261969-05-5.mol |
| 结构式 |  |
H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH 性质
| 储存条件 | Desiccate at -20°C |
|---|---|
| 溶解度 | water, double-distilled: soluble |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 1 mg/ml in water |
|
Ca 2+
|
CALP3 (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca
2+
]
i
in a dose-dependent manner (IC
50
=37.25 μM) in Fura-2-loaded neuronal cultures.
CALP3 (50, 100, 150, 200 μM) inhibits glutamate-induced cytotoxicity in a dose-dependent manner (IC
50
=50.97 μM) in cultured rat neocortical neurons. CALP3 causes dose-dependent inhibition of apoptosis (IC
50
=33.41 μM).
CALP3 (100 μM) inhibits apoptosis induced by HIV gp120 and SAg in Human T cells.
CALP3 (100 μM; 15 min pretreatment) reduces gossypol-induced necrosis and increases the fraction of live cells.
Cyclic-CALP3 is synthesized starting from Fmoc-Asp(PEG-PS)-OAl. Cyclic CALP3 is unable to inhibit Ca21 influx, and this peptide served as a negative control. Cyclic CALP3 does not inhibit the effect of glutamate.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-P1075 | H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH CALP3 | 261969-05-5 | 1mg | 550元 |
| 2026/06/05 | HY-P1075 | H-VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS-OH CALP3 | 261969-05-5 | 5mg | 950元 |