- 4,5-DIBROMOVERATROLE
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- $1.00 / 1KG
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2019-07-12
- CAS:37895-73-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | 4,5-DIBROMOVERATROLE Basic information |
| Product Name: | 4,5-DIBROMOVERATROLE | | Synonyms: | 1,2-DIBROMO-4,5-DIMETHOXYBENZENE;4,5-DIBROMOVERATROL;4,5-DIBROMOVERATROLE;4,5-Dibromoveratrole, 98+%;Einecs 253-705-2;4,5-Dibromo-1,2-dimethoxybenzene;4,5-DIBROMOVERATROLEC8H8Br2O2;Benzene, 1,2-dibromo-4,5-dimethoxy- | | CAS: | 37895-73-1 | | MF: | C8H8Br2O2 | | MW: | 295.96 | | EINECS: | 253-705-2 | | Product Categories: | | | Mol File: | 37895-73-1.mol |  |
| | 4,5-DIBROMOVERATROLE Chemical Properties |
| Melting point | 90-92°C | | Boiling point | 286.6±35.0 °C(Predicted) | | density | 1.742±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | powder to crystal | | color | White to Orange to Green | | Water Solubility | Insoluble in water. | | BRN | 1953148 | | InChI | InChI=1S/C8H8Br2O2/c1-11-7-3-5(9)6(10)4-8(7)12-2/h3-4H,1-2H3 | | InChIKey | ZYCLQXMMFJREPJ-UHFFFAOYSA-N | | SMILES | C1(Br)=CC(OC)=C(OC)C=C1Br |
| Safety Statements | 22-24/25 | | HS Code | 2909303840 |
| Provider | Language |
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ALFA
| English |
| | 4,5-DIBROMOVERATROLE Usage And Synthesis |
| Uses | 4,5-Dibromoveratrole is used as chemical intermediates. | | Synthesis | General procedure for the synthesis of 1,2-dibromo-4,5-dimethoxybenzene from o-anisidine: 16.16 g (117 mmol) of 1,2-dimethoxybenzene was dissolved in 120 mL of carbon tetrachloride at 0 °C with stirring. 13.2 mL (257.4 mmol, 41.13 g) of bromine (2.2 eq.) dissolved in 25 mL of carbon tetrachloride was slowly added dropwise for a controlled time of 30 min while maintaining the reaction temperature in the range of 0-5 °C (by inserting bubbles into the reaction solution to expel the hydrogen bromide generated and neutralizing with Na2CO3). After dropwise addition, the reaction mixture was continued to be stirred at 0°C for 2 hours. Upon completion of the reaction, the mixture was poured into an ice-water mixture, and the organic phase was separated and washed sequentially with 10% aqueous NaHSO3 and 10% aqueous NaOH. The organic phase was concentrated by evaporation and dried to give 33.42 g of white solid product as 1,2-dibromo-4,5-dimethoxybenzene in 97% yield. The melting point of the product was unspecified.1H NMR (CDCl3): δ=7.06 (s, 2H); 3.86 (s, 6H).13C NMR (CDCl3): δ=148.8; 115.9; 114.7; 56.2. | | References | [1] Tetrahedron Letters, 2004, vol. 45, # 37, p. 6851 - 6853
[2] CrystEngComm, 2011, vol. 13, # 20, p. 6050 - 6056
[3] Chemistry - An Asian Journal, 2012, vol. 7, # 10, p. 2240 - 2252
[4] Patent: US8859763, 2014, B1. Location in patent: Page/Page column 5
[5] Chemistry - A European Journal, 2016, vol. 22, # 24, p. 8113 - 8123 |
| | 4,5-DIBROMOVERATROLE Preparation Products And Raw materials |
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