- A-366
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- $68.00
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2026-06-11
- CAS:1527503-11-2
- Purity: 99.27%
- Supply Ability: 10g
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| | 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Basic information |
| Product Name: | 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine | | Synonyms: | CS-2077;A-366; A366;A 366;5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine;5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine;A-336;Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-;11,selective,cells,peptide-competitive,epigenetics,Inhibitor,interaction,inhibit,H3K4me3,Epigenetic Reader Domain,leukemia,Histone Methyltransferase,methyltransferase;A-366,MV4 | | CAS: | 1527503-11-2 | | MF: | C19H27N3O2 | | MW: | 329.44 | | EINECS: | 808-907-0 | | Product Categories: | | | Mol File: | 1527503-11-2.mol | ![5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Structure](CAS/20180702/GIF/1527503-11-2.gif) |
| | 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Chemical Properties |
| Boiling point | 533.6±60.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO : 50 mg/mL (151.77 mM; Need ultrasonic) | | form | powder | | pka | 10.18±0.20(Predicted) | | color | white to beige | | InChI | InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) | | InChIKey | BKCDJTRMYWSXMC-UHFFFAOYSA-N | | SMILES | C12(C3=C(N=C1N)C=C(OCCCN1CCCC1)C(OC)=C3)CCC2 |
| RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Acute 1 |
| | 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Usage And Synthesis |
| Uses | A-366 acts as a potent peptide-competitive inhibitor of the lysine methyltransferase G9a. 1000 fold selectivity over other methyl transferases. | | Biochem/physiol Actions | A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC50 values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc | | in vivo | A-366 (30 mg/kg; osmotic mini-pump; daily for 14 days) treatment of MV4;11 xenografts elicits growth inhibition[4]. | Animal Model: | 6-8 week old SCID-beige female mice (MV4;11 xenografts)[4] | | Dosage: | 30 mg/kg | | Administration: | By osmotic mini-pump; daily for 14 days | | Result: | A modest 45% tumor growth inhibition resulting from A-366 treatment in this model.
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| | IC 50 | EHMT2/G9a/KMT1C; EHMT1/GLP/KMT1D | | storage | Store at -20°C |
| | 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Preparation Products And Raw materials |
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