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- Thiol-PEG3-acid
-
-
2025-06-07
- CAS:1347750-82-6
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | Thiol-PEG3-acid Basic information |
| Product Name: | Thiol-PEG3-acid | | Synonyms: | Thiol-PEG3-acid;Thiol-PEG3-propionic acid;SH-PEG3-COOH;HS-PEG3-COOH;Propanoic acid, 3-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]-;3-(2-(2-(2-Mercaptoethoxy)ethoxy)ethoxy)propanoic acid;SH-PEG3-PA;3-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]propanoic acid | | CAS: | 1347750-82-6 | | MF: | C9H18O5S | | MW: | 238.3 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1347750-82-6.mol |  |
| | Thiol-PEG3-acid Chemical Properties |
| Boiling point | 377.5±37.0 °C(Predicted) | | density | 1.163±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | pka | 4.28±0.10(Predicted) | | form | Liquid | | Appearance | Colorless to light yellow Liquid |
| | Thiol-PEG3-acid Usage And Synthesis |
| Description | Thiol-PEG3-acid is a PEG linker containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Thiol-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Thiol-PEG3-acid Preparation Products And Raw materials |
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