2-(Methylthio)pyrimidine-5-boronic acid pinacol ester manufacturers
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| Product Name: | 2-(Methylthio)pyrimidine-5-boronic acid pinacol ester | | Synonyms: | 2-(Methylthio)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine;PyriMidine,2-(Methylthio)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;2-(Methylthio)pyrimidinyl-5-boronic acid pinacol ester;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-(methylthio)pyrimidin-5-yl)boronate;2-(methylsulfanyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine;2-(METHYLTHIO)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH;2-(Methylthio)pyrimidine-5-boronic acid pinacol ester | | CAS: | 940284-18-4 | | MF: | C11H17BN2O2S | | MW: | 252.14 | | EINECS: | 200-258-5 | | Product Categories: | Organoborons;Pyrimidine | | Mol File: | 940284-18-4.mol |  |
| | 2-(Methylthio)pyrimidine-5-boronic acid pinacol ester Chemical Properties |
| Melting point | 73-78°C | | storage temp. | 2-8°C |
| WGK Germany | 3 | | HS Code | 2933599590 |
| | 2-(Methylthio)pyrimidine-5-boronic acid pinacol ester Usage And Synthesis |
| Synthesis | At room temperature and under argon atmosphere, 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bis(1,3,2-dioxaborhexacyclopentane) (1.77 g, 6.95 mmol), potassium acetate (1.36 g, 13.90 mmol), and palladium diacetate (104 mg, 0.463 mol) were added to a stirred solution of 5-bromo-2-(methylthio)pyrimidine (950 mg, 4.63 mmol) in DMF (5 mL). The resulting suspension was degassed with argon for 15 min and then heated overnight at 85 °C. The reaction mixture was cooled to room temperature. EtOAc (10 mL) was added to the reaction mixture, and the reaction mixture was washed with brine (15 mL x 3). The organic phase was dried (MgSO4), filtered, and concentrated. 
| | Application | Studies have reported that 2-methylthiopyrimidine-5-boronic acid pinaester can be used to prepare the following intermediate, which can be used to prepare substituted imidazo[1,2-a]pyridine derivatives. |
| | 2-(Methylthio)pyrimidine-5-boronic acid pinacol ester Preparation Products And Raw materials |
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