ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Agonist Inhibitors >N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Suppliers list
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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide manufacturers

  • PIM447
  • PIM447 pictures
  • $113.00
  • 2026-07-15
  • CAS:1210608-43-7
  • Purity: 98.97%
  • Supply Ability: 10g
  • PIM447
  • PIM447 pictures
  • $113.00
  • 2026-07-15
  • CAS:1210608-43-7
  • Purity: 98.97%
  • Supply Ability: 10g
  • PIM447
  • PIM447 pictures
  • $118.00
  • 2025-06-30
  • CAS:1210608-43-7
  • Purity: 98.97%
  • Supply Ability: 10g
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Basic information
Product Name:N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
Synonyms:N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide;PIM447 (LGH447);PIM447 (LGH447) Free Base;EOS-60671;2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-;PIM447;N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide (ACI)
CAS:1210608-43-7
MF:C24H23F3N4O
MW:440.46
EINECS:
Product Categories:
Mol File:1210608-43-7.mol
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Structure
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Chemical Properties
Boiling point 493.7±45.0 °C(Predicted)
density 1.290±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:88.0(Max Conc. mg/mL);199.79(Max Conc. mM)
Ethanol:88.0(Max Conc. mg/mL);199.79(Max Conc. mM)
form Solid
pka1.35±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Usage And Synthesis
UsesPIM kinases promote growth and survival of tumor cells and are expressed in a wide variety of human cancers. These kinases are potential therapeutic targets. PIM447 is a PIM kinase inhibitor.
in vivo

PIM447 (100 mg/kg; p.o.; 5 times for a week) reduces tumor burden[2].

Animal Model:6-week-old female NOD-SCID-IL-2Rγ/(NSG) mice (bearing RPMI-8226-luc cells)[2]
Dosage:100 mg/kg
Administration:p.o.; 5 times for a week
Result:Clearly controlled tumor progression as measured by bioluminescence.
IC 50PIM1; PIM2; PIM3
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Preparation Products And Raw materials
Tag:N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide(1210608-43-7) Related Product Information
2-Pyridinecarboxamide, N-[4-[(1S,3R,5R)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-, hydrochloride (1:2) 2-Pyridinecarboxamide, 6-(2,6-difluorophenyl)-5-fluoro-N-[4-[(1R,3S,5S)-3-hydroxy-5-methylcyclohexyl]-3-pyridinyl]- N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Doxorubicin hydrochloride Ruxolitinib