Iodophenpropit dihydrobromide
| 中文名称 | Iodophenpropit dihydrobromide |
|---|---|
| 中文同义词 | 化合物 T15590;化合物 IODOPHENPROPIT DIHYDROBROMIDE |
| 英文名称 | Iodophenpropit dihydrobromide |
| 英文同义词 | Iodophenpropit hydrobromide |
| CAS号 | 145196-87-8 |
| 分子式 | C15H20BrIN4S |
| 分子量 | 495.22 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 145196-87-8.mol |
| 结构式 |  |
Iodophenpropit dihydrobromide 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO:50.0(最大浓度 mg/mL);86.79(最大浓度 mM) 水:32.2(最大浓度 mg/mL);55.89(最大浓度 mM) |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 25 mM in water |
| InChI | InChI=1S/C15H19IN4S.BrH/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14;/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20);1H |
| InChIKey | HQCDATXHTXCVHB-UHFFFAOYSA-N |
| SMILES | C(C1C=CC(I)=CC=1)CNC(=N)SCCCC1N=CNC=1.Br |
Iodophenpropit dihydrobromide 是一种有效的选择性组胺 H3 受体 (histamine H3 receptor) 拮抗剂。[125I] Iodophenpropit 结合 H3 受体具有选择性，可饱和，易于可逆，及高亲和力 (KD 为 0.32 nM)。
|
H 3 Receptor 0.32 nM (Kd) |
Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor.
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC
50
of 1.57±0.3 μM.
Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits.
| Animal Model: | New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg |
| Dosage: | 1 μg/kg |
| Administration: | Administered through intramuscular (i.m.); b.i.d.; for 10 days |
| Result: | Could influence a detectable antibody response to SRBC. |