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| | Acid-PEG3-PFP ester Basic information |
| Product Name: | Acid-PEG3-PFP ester | | Synonyms: | Acid-PEG3-PFP ester;Propanoic acid, 3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]-, 1-(2,3,4,5,6-pentafluorophenyl) ester | | CAS: | 1835759-67-5 | | MF: | C16H17F5O7 | | MW: | 416.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1835759-67-5.mol |  |
| | Acid-PEG3-PFP ester Chemical Properties |
| Boiling point | 485.9±45.0 °C(Predicted) | | density | 1.416±0.06 g/cm3(Predicted) | | pka | 4.28±0.10(Predicted) |
| | Acid-PEG3-PFP ester Usage And Synthesis |
| Description | Acid-PEG3-PFP ester is a PEG linker containing a carboxylic acid and PFP ester end group. The carboxylic acid can react with amines in the presence of activators such as EDC and HATU to form a stable amide bond. The PFP ester can also react with amine groups. The hydrophilic PEG chains increase the water solubility of the compound in aqueous media. | | Uses | Acid-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Acid-PEG3-PFP ester Preparation Products And Raw materials |
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