N3-PEG5-CH2COOH manufacturers
- N3-PEG5-CH2COOH
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2026-07-24
- CAS:
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | N3-PEG5-CH2COOH Basic information |
| Product Name: | N3-PEG5-CH2COOH | | Synonyms: | AZIDE-PEG5-CH2COOH;N3-PEG5-CH2COOH;Azido-PEG5-CH2CO2H;N3-PEG5-CH2CO2H;17-azido-3,6,9,12,15-pentaoxaheptadecanoic acid;2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid;Azido-PEG5-CH2COOH | | CAS: | 217180-81-9 | | MF: | C12H23N3O7 | | MW: | 321.33 | | EINECS: | | | Product Categories: | peg | | Mol File: | 217180-81-9.mol |  |
| | N3-PEG5-CH2COOH Chemical Properties |
| storage temp. | -20°C, protect from light | | form | Liquid | | color | Colorless to light yellow |
| | N3-PEG5-CH2COOH Usage And Synthesis |
| Description | Azido-PEG5-CH2CO2H is a water soluble PEG linker. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide. | | Uses | Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Cleavable Linker; PEGs | | References | [1] Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1. |
| | N3-PEG5-CH2COOH Preparation Products And Raw materials |
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