N3-PEG8-CH2COOH manufacturers
- N3-PEG8-CH2COOH
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2026-07-24
- CAS:1343472-07-0
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | N3-PEG8-CH2COOH Basic information |
| Product Name: | N3-PEG8-CH2COOH | | Synonyms: | N3-PEG8-CH2COOH;AZIDE-PEG8-CH2COOH;Azido-PEG8-CH2CO2H;N3-PEG8-CH2CO2H;N3-PEG8-CH2COOH/3,6,9,12,15,18,21,24-Octaoxahexacosanoic acid, 26-azido-;26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosanoic acid | | CAS: | 1343472-07-0 | | MF: | C18H35N3O10 | | MW: | 453.49 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1343472-07-0.mol |  |
| | N3-PEG8-CH2COOH Chemical Properties |
| storage temp. | Store at Room Tem. |
| | N3-PEG8-CH2COOH Usage And Synthesis |
| Description | Azido-PEG8-CH2CO2H is a aqueous soluble PEG linker. The hydrophilic PEG spacer increases solubility in aqueous media. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | N3-PEG8-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. N3-PEG8-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] Steinmetz NF, et al. Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors. Small. 2011 Jun 20;7(12):1664-72. DOI:10.1002/smll.201000435 |
| | N3-PEG8-CH2COOH Preparation Products And Raw materials |
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