2-N-Boc-amino-3-formylpyridine manufacturers
|
| | 2-N-Boc-amino-3-formylpyridine Basic information | | Uses |
| Product Name: | 2-N-Boc-amino-3-formylpyridine | | Synonyms: | Carbamic acid, N-(3-formyl-2-pyridinyl)-, 1,1-dimethylethyl ester;tert-butyl N-(3-forMylpyridin-2-yl)carbaMate;2-N-BOC-AMINO-3-FORMYLPYRIDINE;2-BOC-AMINO-3-FORMYLPYRIDINE;(3-FORMYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER;TERT-BUTYL 3-FORMYLPYRIDIN-2-YLCARBAMATE;REF DUPL: 2-N-Boc-amino-3-formylpyridine;ert-butylN-(3-formylpyridin-2-yl)carbamate | | CAS: | 116026-94-9 | | MF: | C11H14N2O3 | | MW: | 222.24 | | EINECS: | | | Product Categories: | Pyridines | | Mol File: | 116026-94-9.mol |  |
| | 2-N-Boc-amino-3-formylpyridine Chemical Properties |
| Melting point | 109-111 °C | | Boiling point | 310 °C | | density | 1.212 | | Fp | 141 °C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 12.05±0.70(Predicted) |
| | 2-N-Boc-amino-3-formylpyridine Usage And Synthesis |
| Uses | 2-Boc-amino-3-pyridinecarboxaldehyde can be used as a pharmaceutical synthesis intermediate. It can be prepared by reacting 2-aminopyridine with (Boc)2O protecting group to prepare intermediate 2-(tert-butyloxycarbonylamino)pyridine, which is then reacted with tert-butyllithium and DMF to obtain the final product. | | Synthesis | Step 2: Synthesis of tert-butyl 3-formylpyridin-2-ylcarbamate (9b)
To a solution of compound 9a (14.0 g, 72 mmol) in anhydrous ether (500 mL) at -78 °C and under nitrogen protection, tert-butyllithium (1.7 M, 106 mL, 180 mmol) was slowly added. The reaction mixture was slowly warmed to 0 °C and stirred at this temperature for 1 hour. Subsequently, anhydrous N,N-dimethylformamide (8.0 mL, 103 mmol) was added rapidly under vigorous stirring. The reaction mixture was continued to be stirred at 0 °C for 10 min and then quenched with a half-saturated aqueous ammonium chloride solution. The aqueous layer was separated and extracted twice with ethyl acetate (EA). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 3/1) to afford the target product 9b (8.0 g, 52% yield) as a white solid. | | References | [1] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 45
[2] Heterocyclic Communications, 2011, vol. 17, # 1-2, p. 21 - 23 |
| | 2-N-Boc-amino-3-formylpyridine Preparation Products And Raw materials |
|