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| | N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) Basic information |
| | N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) Chemical Properties |
| solubility | Soluble in DMSO, DCM. DMF |
| | N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) Usage And Synthesis |
| Description | N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is developed as a branched PEG linker with a terminal azide group and two t-butyl esters. The azide group enables PEGylation via Click Chemistry. The t-butyl protected carboxyl groups can be deprotected under mild acidic conditions. | | Uses | N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) Preparation Products And Raw materials |
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