羟基氯喹EP杂质D-d5二盐酸
| 中文名称 | 羟基氯喹EP杂质D-d5二盐酸 |
|---|---|
| 中文同义词 | 羟氯喹硫酸EP杂质D DIHBR;脱乙基氯喹DIHBR(硫酸羟氯喹EP杂质D DIHBR);羟基氯喹EP杂质D;羟氯喹杂质9 2HBR;脱乙基氯喹;氯喹相关物质D;去乙基氯喹;去乙基氯喹-D4 |
| 英文名称 | DESETHYL CHLOROQUINE |
| 英文同义词 | DESETHYL CHLOROQUINE;Deethylchloroquine;Desethyl Chloroquine DiHBr (Hydroxychloroquine Sulfate EP Impurity D DiHBr);Hydroxychloroquine Sulfate EP Impurity D DiHBr;Chloroquine Impurity 1（Desethyl Chloroquine）;Hydroxychloroquine Sulfate Impurity 4（Hydroxychloroquine Sulfate EP Impurity D）;Hydroxychloroquine Impurity 9 2HBr;Monodeethylchloroquine |
| CAS号 | 1476-52-4 |
| 分子式 | C16H22ClN3 |
| 分子量 | 291.82 |
| EINECS号 | |
| 相关类别 | 化学试剂;对照品-杂质对照品;杂质对照品;Metabolite;Various Metabolites and Impurities;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals |
| Mol文件 | 1476-52-4.mol |
| 结构式 |  |
羟基氯喹EP杂质D-d5二盐酸 性质
| 熔点 | 94-97C |
|---|---|
| 沸点 | 173-175 °C(Press: 0.05 Torr) |
| 密度 | 1.138±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于氯仿（少量）、二氯甲烷（少量）、乙酸乙酯（少量） |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.62±0.19(Predicted) |
| 颜色 | 浅黄色至深黄色 |
| 生物来源 | synthetic |
| InChI | 1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20) |
| InChIKey | MCYUUUTUAAGOOT-UHFFFAOYSA-N |
| SMILES | ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2 |
Desethyl chloroquine 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine 具有抗疟原虫活性。
P. falciparum
Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.
安全信息
| WGK Germany | 3 |
|---|---|
| 海关编码 | 2933497050 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-135811 | 羟基氯喹EP杂质D-d5二盐酸 Desethyl chloroquine | 1476-52-4 | 2.5 mg | 6180元 |
| 2024/11/08 | HY-135811 | Desethyl chloroquine | 2500 μg | 6180元 |