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| | DOLASTATIN 15 Basic information |
| Product Name: | DOLASTATIN 15 | | Synonyms: | Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline;DOLASTATIN 15;(5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one;L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-;L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-;Nsc 617668;(5S)-1-[(2S)-O-(N,N-DIMETHYL-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE;(5S)-1-[(2S)-O-(N,N-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE | | CAS: | 123884-00-4 | | MF: | C45H68N6O9 | | MW: | 837.06 | | EINECS: | | | Product Categories: | | | Mol File: | 123884-00-4.mol |  |
| | DOLASTATIN 15 Chemical Properties |
| Boiling point | 954.0±65.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Methanol: soluble | | pka | 13.88±0.46(Predicted) | | form | White solid. |
| | DOLASTATIN 15 Usage And Synthesis |
| Uses | Dolastatin 15 is an apoptotic agent through Blc-2 phosphorylation. | | in vivo | Dolastatin 15 conjugates to Trastuzumab via lysine residues at the drug C-terminus using a non-cleavable linker (Trastuzumab-amide-C-term-Dol15) produced target-dependent growth inhibition of cells endogenously expressing high HER2 levels (i.e., SK-BR-3, SK-OV-3) in vitro. This ADC was effective at varying doses (i.e., 10 and 20 mg/kg) in the SK-OV-3 human ovarian cancer xenograft[3]. | | IC 50 | Auristatin |
| | DOLASTATIN 15 Preparation Products And Raw materials |
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