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| | 9beta,11alpha,15S-trihydroxy-prosta-5z,13e-dien-1-oic acid, Tris (hydroxymethyl)aminomethane salt Basic information |
| Product Name: | 9beta,11alpha,15S-trihydroxy-prosta-5z,13e-dien-1-oic acid, Tris (hydroxymethyl)aminomethane salt | | Synonyms: | 9BETA-PGF2ALPHA (TROMETHAMINE SALT);PROSTAGLANDIN F2BETA TROMETHAMINE SALT;2-amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5R)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoate;Prostaglandin F2β (tromethamine salt);(5R)-Dinoprost tromethamine;9beta,11alpha,15S-trihydroxy-prosta-5z,13e-dien-1-oic acid, Tris (hydroxymethyl)aminomethane salt | | CAS: | 89847-02-9 | | MF: | C24H45NO8 | | MW: | 475.62 | | EINECS: | | | Product Categories: | | | Mol File: | 89847-02-9.mol |  |
| | 9beta,11alpha,15S-trihydroxy-prosta-5z,13e-dien-1-oic acid, Tris (hydroxymethyl)aminomethane salt Chemical Properties |
| solubility | Acetone: >5 mg/ml (from PGF2a THAM); Acetonitrile: >5 mg/ml (from PGF2a THAM); DMSO: >50 mg/ml (from PGF2a THAM); Ethanol: >50 mg/ml (from PGF2a THAM); Methanol: >100 mg/ml (from PGF2a THAM); PBS pH 7.2: >25 mg/ml (from PGF2a THAM) | | form | A crystalline solid |
| | 9beta,11alpha,15S-trihydroxy-prosta-5z,13e-dien-1-oic acid, Tris (hydroxymethyl)aminomethane salt Usage And Synthesis |
| Description | Prostaglandin F2β (PGF2β) (tromethamine salt) is a derivative of PGF2β with increased water solubility. PGF2β is the 9β-hydroxy stereoisomer of PGF2α . It is much less active than PGF2α in antifertility and bronchoconstrictor activities. PGF2β exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α. | | Uses | (5R)-Dinoprost tromethamine (Prostaglandin F2β tromethamine) is a metabolite produced by the metabolism of arachidonic acid cyclooxygenase. (5R)-Dinoprost tromethamine induces dose-dependent release of hexosaccharide containing mucin[1][2]. | | References | [1] Lamont JT, et, al. Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release. Gastroenterology. 1983 Feb;84(2):306-13. PMID:6184259
[2] Jang Y, et, al. Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J Neuroinflammation. 2020 Jan 22;17(1):30. DOI:10.1186/s12974-020-1703-1 |
| | 9beta,11alpha,15S-trihydroxy-prosta-5z,13e-dien-1-oic acid, Tris (hydroxymethyl)aminomethane salt Preparation Products And Raw materials |
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