- Pheophorbide A
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- $10.00 / 1ASSAYS
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2025-09-15
- CAS:15664-29-6
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 1 ton
- Pheophorbide a
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- $42.00 / 5mg
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2025-09-11
- CAS:15664-29-6
- Min. Order:
- Purity: 99.99%
- Supply Ability: 10g
- Pheophorbide A
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- $6.00 / 1KG
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2025-03-28
- CAS:15664-29-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20TONS
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| | Pheophorbide A Basic information |
| Product Name: | Pheophorbide A | | Synonyms: | PHEOPHORBIDE A;[3s-(3alpha,4beta,21beta)]-ramethyl-20-oxo;3-phorbinepropanoicacid,9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tet;[3S-(3alpha,4beta,21beta)]-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinylphorbine-3-propionic acid;(3S,4S)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;13-Epi-phaeophorbide-a;3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S)-;Inchi=1/C35H36N4o5/C1-8-19-15(3)22-12-24-17(5)21(10-11-28(40)41)32(38-24)30-31(35(43)44-7)34(42)29-18(6)25(39-33(29)30)14-27-20(9-2)16(4)23(37-27)13-26(19)36-22/H8,12-14,17,21,31,36,39H,1,9-11H2,2-7H3,(H,40,41)/B22-12-,23-13-,24-12-,25-14-,26-13-,27-14- | | CAS: | 15664-29-6 | | MF: | C35H36N4O5 | | MW: | 592.7 | | EINECS: | 239-738-5 | | Product Categories: | Natural Porphyrins and Derivitives;Porphyrins;Elisa Kit-plant ELISA Kit | | Mol File: | 15664-29-6.mol |  |
| | Pheophorbide A Chemical Properties |
| Melting point | 191-195 °C | | Boiling point | 1019.0±65.0 °C(Predicted) | | density | 1.282±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO: soluble0.5mg/mL, clear (warmed) | | form | Solid | | color | blue, to dark brown to black | | Stability: | Light Sensitive | | EPA Substance Registry System | 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6) |
| | Pheophorbide A Usage And Synthesis |
| Uses | Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity. | | Uses | Pheophorbide-a has been used as a photosensitizer:
- for the photodynamic therapy (PDT) in oral cancer cell lines
- to test its effect on inducing oxidative stress and death in L. amazonensis
- to test its effect on the viability of HeLa cells
| | Definition | ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-). | | Biochem/physiol Actions | Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype. | | in vivo | Pheophorbide A-mediated photodynamic therapy (Pa-PDT) (10 mg/kg (i.v.) or 30 mg/kg (i.p.)) significantly inhibits tumor growth in C3H mouse model with subcutaneous injection of AT-84 cells[3]. | Animal Model: | Male immunocompetent C3H mouse (six-week-old, inoculated subcutaneously with AT-84 cells)[3] | | Dosage: | 10 mg/kg intravenous (i.v.) or a 30 mg/kg intraperitoneal (i.p.) injection | | Administration: | IV or IP; after 24 h, PDT was performed | | Result: | Pa-PDT, especially i.v. Pa-PDT, significantly inhibited tumor growth up to 70%, while the i.p. Pa-PDT-induced inhibition was up to 43.4% relative to the control group at the end of period. |
| | Enzyme inhibitor | This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter. |
| | Pheophorbide A Preparation Products And Raw materials |
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