|
|
| | 2-Amino-6-fluoropyridine Basic information |
| | 2-Amino-6-fluoropyridine Chemical Properties |
| Melting point | 59-61°C | | Boiling point | 225.0±20.0 °C(Predicted) | | density | 1.257±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 2.26±0.24(Predicted) | | color | White to Almost white | | InChI | InChI=1S/C5H5FN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8) | | InChIKey | UZALKVXCOUSWSL-UHFFFAOYSA-N | | SMILES | C1(N)=NC(F)=CC=C1 | | CAS DataBase Reference | 1597-32-6(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 6.1 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2-Amino-6-fluoropyridine Usage And Synthesis |
| Description | 2-Amino-6-fluoropyridine is an organic intermediate that can be prepared via the nucleophilic substitution reaction of 2,6-difluoropyridine with ammonia. | | Uses | 2-Amino-6-fluoropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Synthesis | The general procedure for the synthesis of 2-amino-6-fluoropyridine from 2,6-difluoropyridine was as follows: 2,6-difluoropyridine (50 g, 434 mmol) was dissolved in ammonium hydroxide solution (200 mL, 28.0-30.0%) in a steel tube and the reaction was heated for 15 hr at 105 °C. Upon completion of the reaction, the mixture was cooled in an ice bath and the precipitate was subsequently collected by filtration. The precipitate was washed with cold water and dried to give 6-fluoro-2-pyridinamine (45.8 g, 94% yield) as a white solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 7.53 (m, 1H), 6.36 (dd, 1H), 6.26 (dd, 1H), 4.56 (s, 2H). | | References | [1] Patent: WO2006/76131, 2006, A2. Location in patent: Page/Page column 39-40
[2] Patent: WO2007/27999, 2007, A2. Location in patent: Page/Page column 35
[3] Patent: WO2006/36816, 2006, A2. Location in patent: Page/Page column 59-60
[4] Patent: WO2006/26703, 2006, A2. Location in patent: Page/Page column 64-65
[5] Patent: WO2007/87549, 2007, A2. Location in patent: Page/Page column 44; 59 |
| | 2-Amino-6-fluoropyridine Preparation Products And Raw materials |
|