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| | H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH Basic information |
| Product Name: | H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH | | Synonyms: | OVALBUMIN CHICKEN (323-339);OVALBUMIN (323-339) (CHICKEN, JAPANESE QUAIL);OVA (323-339);OVA (323-339) (CHICKEN, JAPANESE QUAIL);H2N-ISQAVHAAHAEINEAGR-OH;L-Arginine,L-isoleucyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-histidyl-L-alanyl-L-alanyl-L-histidyl-L-alanyl-L-a-glutamyl-L-isoleucyl-L-asparaginyl-L-a-glutamyl-L-alanylglycyl-;ILE-SER-GLN-ALA-VAL-HIS-ALA-ALA-HIS-ALA-GLU-ILE-ASN-GLU-ALA-GLY-ARG;ISQAVHAAHAEINEAGR | | CAS: | 92915-79-2 | | MF: | C74H120N26O25 | | MW: | 1773.91 | | EINECS: | | | Product Categories: | Peptide;Various Peptides | | Mol File: | 92915-79-2.mol |  |
| | H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH Chemical Properties |
| density | 1.52±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | water, double-distilled: soluble | | form | lyophilized powder | | pka | 3.33±0.10(Predicted) | | color | white | | Water Solubility | water, double-distilled: soluble | | Sequence | Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH Usage And Synthesis |
| Uses | Ovalbumin (323-339) (chicken, Japanese quail) has been used to induce allergic asthma in mice. | | General Description | Ovalbumin (323-339) is an egg white protein surrounded by B-cell epitopes, which are bound by specific IgE antibodies. In addition to this, it also contains CD4+ T cell epitopes. | | Biochem/physiol Actions | With the help of two functionally distinct registers ovalbumin (323-339) peptide can bind to histocompatibility complex class II I-A(d) protein. | | in vivo | OVA Peptide (323-339) represents a T and B cell epitope of OVA, which is important in the generation and development of immediate hypersensitivity responses in BALB/c mice. Daily aerosolization of OVA Peptide (323-339) for 20 minutes over a period of 10 days has been as effective in the stimulation of a serum anti-OVA IgE antibody response as sensitization to native OVA by the same route. After sensitization to native OVA, the majority of the IgE anti-OVA response is directed against OVA Peptide (323-339). Evaluated by hematoxylin/eosin and major basic protein immunohistochemical stainings, OVA and OVA Peptide (323-339) induce similar lung inflammation. Interestingly, significant serum total IgE and OVA-specific IgE are observed in OVA mice when compared to saline control. OVA Peptide (323-339) mice show higher serum OVA-specific IgE, OVA Peptide (323-339)-specific IgE, IL-4 and lower IFN-γ similar to OVA mice. The proliferative response to OVA is found in cultured splenocytes of both OVA and OVA Peptide (323-339) mice, while the similar proliferative response to OVA Peptide (323-339) is only observed in the splenocytes of OVA Peptide (323-339)-sensitized and challenged mice. Although OVA Peptide (323-339) induces a Th2-like response in the mouse model as does OVA, OVA Peptide (323-339) has clearly limited immunogenic potency to activate OVA-sensitized and challenged mice splenocytes, unlike OVA[2]. |
| | H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH Preparation Products And Raw materials |
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