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Sigma-Aldrich |
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| | N1-Acetylspermine trihydrochloride Basic information |
| Product Name: | N1-Acetylspermine trihydrochloride | | Synonyms: | 1-ACETYLSPERMINE TRIHYDROCHLORIDE;N1-Acetylspermine (hydrochloride);N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)acetamide trihydrochloride;N1-Acetylspermine trihydrochloride;Aminocaproic Acid Impurity 23 Trihydrochloride;N1-Acetylspermine trihydrochloride | | CAS: | 77928-70-2 | | MF: | C12H31Cl3N4O | | MW: | 353.76 | | EINECS: | | | Product Categories: | | | Mol File: | 77928-70-2.mol |  |
| | N1-Acetylspermine trihydrochloride Chemical Properties |
| Melting point | >256°C (dec.) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White | | BRN | 7052482 | | InChI | 1S/C12H28N4O.3ClH/c1-12(17)16-11-5-10-15-8-3-2-7-14-9-4-6-13;;;/h14-15H,2-11,13H2,1H3,(H,16,17);3*1H | | InChIKey | QQSPUTBJDXPUCR-UHFFFAOYSA-N | | SMILES | Cl[H].Cl[H].Cl[H].CC(=O)NCCCNCCCCNCCCN |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | N1-Acetylspermine trihydrochloride Usage And Synthesis |
| Description | N1-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16. | | Uses | N1-Acetylspermine trihydrochloride has been used in a study to determine that the human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. | | References | [1] MUSTAPHA AOUIDA Dindial R Richard Poulin. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.[J]. The Journal of Biological Chemistry, 2010: 6275-6284. DOI: 10.1074/jbc.m109.046151 |
| | N1-Acetylspermine trihydrochloride Preparation Products And Raw materials |
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