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| | 4-(5-Carboxy-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester Basic information |
| Product Name: | 4-(5-Carboxy-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | | Synonyms: | 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]nicotinicacid97%;6-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]NICOTINIC ACID;6-[4-(PIPERAZIN-1-YL)]NICOTINIC ACID, N4-BOC PROTECTED;6-Piperazin-1-ylnicotinic acid, N4-BOC protected;6-Piperazin-1-ylnicotinic acid, N4-BOC protected 97%;N4-BOC-6-PIPERAZIN-1-YLNICOTINIC ACID;6-[4-(tert-butoxycarbonyl)piperazino]nicotinic acid;6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-carboxylic acid | | CAS: | 201809-22-5 | | MF: | C15H21N3O4 | | MW: | 307.34 | | EINECS: | | | Product Categories: | | | Mol File: | 201809-22-5.mol |  |
| | 4-(5-Carboxy-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties |
| Melting point | 298 °C | | Boiling point | 497.4±45.0 °C(Predicted) | | density | 1.250±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 3.12±0.10(Predicted) |
| Risk Statements | 20/21/22 | | Safety Statements | 24/25-36/37 | | Hazard Note | Harmful | | HazardClass | IRRITANT | | HS Code | 29335990 |
| | 4-(5-Carboxy-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester Usage And Synthesis |
| Chemical Properties | White solid | | Uses | Boc-piperazine-pyridine-COOH is a PROTAC Linker that can be used to synthesize PROTAC YW-N-7 (HY-170855)[1]. | | References | [1] Wang Y, et al. Targeting Oncogenic RET Kinase by Simultaneously Inhibiting Kinase Activity and Degrading the Protein. J Med Chem. 2025 Jan 9;68(1):81-94. DOI:10.1021/acs.jmedchem.4c01424 |
| | 4-(5-Carboxy-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials |
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