PX-13-17OH manufacturers
- PX-13-17OH
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- $797.00
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2026-04-21
- CAS:884539-95-1
- Purity:
- Supply Ability: 10g
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| | PX-13-17OH Basic information |
| Product Name: | PX-13-17OH | | Synonyms: | PX-13-17OH;Cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione, 5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-, (1E,4S,4aR,5R,6aS,7S,9aR)-;(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione;[(1S,3aR,6E,9S,9aR,10R,11aS)-6-[[3-(Dimethylamino)propyl-methylamino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4, 7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-H]isochromen-10-yl] acetate | | CAS: | 884539-95-1 | | MF: | C29H42N2O8 | | MW: | 546.65 | | EINECS: | | | Product Categories: | | | Mol File: | 884539-95-1.mol |  |
| | PX-13-17OH Chemical Properties |
| Boiling point | 662.308±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.283±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 6.198±0.70(predicted) |
| | PX-13-17OH Usage And Synthesis |
| Description | PX-13-17OH is a PI3K inhibitor | | Uses | PI3K-IN-11 (compound 13) is a PI3K inhibitor, which selectively inhibits PI3Kα, PI3Kβ, PI3K, and PI3Kδ (IC50s=6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50=2.9 μM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 μg/mL. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg. | | References | [1] Zask, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: Potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J. Med. Chem. 51(5), 1319-1323 (2008). |
| | PX-13-17OH Preparation Products And Raw materials |
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