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| | eIF4A3 inhibitor 53a Basic information |
| Product Name: | eIF4A3 inhibitor 53a | | Synonyms: | eIF4A3-IN-1;eIF4A3 inhibitor 53a;eIF4A3-IN-1 (compound 53a);Benzonitrile, 3-[4-[[(3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)-1-piperazinyl]carbonyl]-5-methyl-1H-pyrazol-1-yl]-;eIF4A3 IN 1,eIF4A3IN1,eIF-4A3-IN-1 | | CAS: | 2095486-67-0 | | MF: | C29H23BrClN5O2 | | MW: | 588.88 | | EINECS: | | | Product Categories: | | | Mol File: | 2095486-67-0.mol |  |
| | eIF4A3 inhibitor 53a Chemical Properties |
| Boiling point | 769.3±60.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | -1.02±0.12(Predicted) | | form | Solid | | color | White to off-white |
| | eIF4A3 inhibitor 53a Usage And Synthesis |
| Uses | eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1]. | | References | [1] Ito M, et al. Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem. 2017 Apr 27;60(8):3335-3351. DOI:10.1021/acs.jmedchem.6b01904 |
| | eIF4A3 inhibitor 53a Preparation Products And Raw materials |
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