E3 ligase Ligand-Linker Conjugates 6 Free Base manufacturers
- (S,R,S)-AHPC-PEG2-NH2
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2025-06-07
- CAS:2010159-60-9
- Min. Order: 100mg
- Purity: >98.00%
- Supply Ability: 100mg
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| | E3 ligase Ligand-Linker Conjugates 6 Free Base Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 6 Free Base | | Synonyms: | E3 ligase Ligand-Linker Conjugates 6 Free Base;(2S,4R)-1-[(2S)-2-[[2-[2-(2-aminoethoxy)ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;(S,R,S)-AHPC-PEG2-NH2;VH032-PEG2-NH2;VHL Ligand-Linker Conjugates 3;PROTACs Related Compound 6;(S,R. S)-AHPC-PEG2-amine hydrochloride salt;(S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base) | | CAS: | 2010159-60-9 | | MF: | C28H41N5O6S | | MW: | 575.73 | | EINECS: | | | Product Categories: | | | Mol File: | 2010159-60-9.mol |  |
| | E3 ligase Ligand-Linker Conjugates 6 Free Base Chemical Properties |
| Boiling point | 856.9±65.0 °C(Predicted) | | density | 1.249±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, Methanol | | pka | 13.54±0.46(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | E3 ligase Ligand-Linker Conjugates 6 Free Base Usage And Synthesis |
| Description | (S, R, S)-AHPC-PEG2-amine is a synthetic PROTAC linker that incorporates an E3 ligase ligand with a PEG2 unit to empower drug research & discovery. It is reactive with NHS ester or carboxylic acid. | | Uses | (S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1]. | | IC 50 | VHL | | References | [1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Me DOI:10.1021/acs.jmedchem.6b01912 |
| | E3 ligase Ligand-Linker Conjugates 6 Free Base Preparation Products And Raw materials |
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