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| | N-(acid-PEG3)-N-bis(PEG3-azide) Basic information |
| Product Name: | N-(acid-PEG3)-N-bis(PEG3-azide) | | Synonyms: | N-(acid-PEG3)-N-bis(PEG3-azide);N-(acid-PEG)-N-bis(PEG-azide);Propanoic acid, 3-[[20-azido-9-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-3,6,12,15,18-pentaoxa-9-azaeicos-1-yl]oxy]-;(N3-PEG3)2-N-PEG3-COOH | | CAS: | 2182602-17-9 | | MF: | C25H49N7O11 | | MW: | 623.71 | | EINECS: | | | Product Categories: | peg | | Mol File: | 2182602-17-9.mol |  |
| | N-(acid-PEG3)-N-bis(PEG3-azide) Chemical Properties |
| storage temp. | Storage temp. -20°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | N-(acid-PEG3)-N-bis(PEG3-azide) Usage And Synthesis |
| Description | N-(acid-PEG3)-N-bis(PEG3-azide) is a a-arm PEGylation reagent with azide moieties and a terminal carboxylic acid. The azide groups enable Click Chemistry. PEG linker increases the solubility of the compound in aqueous media. | | Uses | N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(acid-PEG3)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(acid-PEG3)-N-bis(PEG3-azide) Preparation Products And Raw materials |
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