N-(Azido-PEG3)-N-bis(PEG4-acid)

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N-(Azido-PEG3)-N-bis(PEG4-acid) manufacturers

N-(Azido-PEG3)-N-bis(PEG4-acid) Basic information
Product Name:N-(Azido-PEG3)-N-bis(PEG4-acid)
Synonyms:N-(Azido-PEG3)-N-bis(PEG4-acid)
CAS:2112731-54-9
MF:C30H58N4O15
MW:714.81
EINECS:
Product Categories:
Mol File:2112731-54-9.mol
N-(Azido-PEG3)-N-bis(PEG4-acid) Structure
N-(Azido-PEG3)-N-bis(PEG4-acid) Chemical Properties
storage temp. 2-8°C, protect from light
form Liquid
color Colorless to light yellow
Safety Information
MSDS Information
N-(Azido-PEG3)-N-bis(PEG4-acid) Usage And Synthesis
DescriptionN-(Azido-PEG3)-N-bis(PEG4-acid) is an aqueous soluble PEG linker that contains azide and carboxylic acid moieties. The azide group can undergo Click Chemistry reactions with alkynes. The carboxylic acid groups can is reactive with amine entity.
UsesN-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Azido-PEG3)-N-bis(PEG4-acid) Preparation Products And Raw materials
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