- Sodium thioctate
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- $2.00
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2026-08-25
- CAS:2319-84-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
- Sodium thioctate
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-
2022-01-27
- CAS:2319-84-8
- Min. Order: 1KG
- Purity: 98.9%
- Supply Ability: 100 tons
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| | Sodium thioctate Basic information |
| Product Name: | Sodium thioctate | | Synonyms: | sodium 5-(1,2-dithiolan-3-yl)pentanoate;ALPHALIPOICACIDSODIUMSALT;Sodium thioctate SODIUM LIPOATE;SODIUM LIPOATE;alpha-Lipoic Acid Sodium;sodium thioctate;Sodium 5-(dithiolan-3-yl)pentanoate;Thioctic acid sodium salt | | CAS: | 2319-84-8 | | MF: | C8H13NaO2S2 | | MW: | 228.31 | | EINECS: | | | Product Categories: | | | Mol File: | 2319-84-8.mol |  |
| | Sodium thioctate Chemical Properties |
| | Sodium thioctate Usage And Synthesis |
| Uses | α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4]. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1[5]. | | in vivo | C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid. Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed. Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice. In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05)[1]. | | IC 50 | HIV-1; NF-κB; Human Endogenous Metabolite; Microbial Metabolite | | References | [1] Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65. DOI:10.1002/biof.5520270114
[2] Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153. DOI:10.18632/oncotarget.24343
[3] Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217. DOI:10.1016/j.jnutbio.2014.06.001
[4] Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139. DOI:10.1038/s41598-020-64004-5
[5] Liu J, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir, 2022. |
| | Sodium thioctate Preparation Products And Raw materials |
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