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| | LXRβ agonist-2 Basic information |
| Product Name: | LXRβ agonist-2 | | Synonyms: | LXRβ agonist-2;LXRβ agonist2,LXRβ agonist 2;2,4-Imidazolidinedione, 3-[2-[2-hydroxy-4-[2-propyl-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenoxy]phenyl]-2-oxoethyl]-5-methyl-5-[5-(1-methylethoxy)-2-pyridinyl]-, (5S)- | | CAS: | 1949801-52-8 | | MF: | C32H31F6N3O7 | | MW: | 683.59 | | EINECS: | | | Product Categories: | | | Mol File: | 1949801-52-8.mol |  |
| | LXRβ agonist-2 Chemical Properties |
| density | 1.373±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 6.21±0.70(Predicted) |
| | LXRβ agonist-2 Usage And Synthesis |
| Uses | LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1]. | | References | [1] Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46. DOI:10.1016/j.bmc.2016.05.048 |
| | LXRβ agonist-2 Preparation Products And Raw materials |
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