顺式-8，11，14-二十烷三烯酸甲酯
| 中文名称 | 顺式-8，11，14-二十烷三烯酸甲酯 |
|---|---|
| 中文同义词 | 顺式-8，11，14-二十烷三烯酸甲酯;顺式-8,11,14-二十碳三烯酸;8,11,14-二十碳三烯酸;二十碳三烯酸(顺-8,11,14);全顺-8,11,14-二十碳三烯酸;顺式 - 8,11,14-二十碳三烯的酸;顺-8,11,14-二十碳三烯酸甲酯 (C20:3N6) 溶液;顺-8,11,14-二十碳三烯酸甲酯 (C20:3N6) |
| 英文名称 | CIS-8,11,14-EICOSATRIENOIC ACID |
| 英文同义词 | DIHOMO-GAMMA-LINOLENIC ACID-CONTAINING TRIGLYCERIDE;EICOSA-8Z,11Z,14Z-TRIENOIC ACID;CIS,CIS,CIS-8,11,14-EICOSATRIENOIC ACID;CIS-8,11,14-EICOSATRIENOIC ACID;DELTA 8 CIS 11 CIS 14 CIS EICOSATRIENOIC ACID;HOMO-GAMMA-LINOLENIC ACID;homo-γ-linolenic acid;(6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid |
| CAS号 | 1783-84-2 |
| 分子式 | C20H34O2 |
| 分子量 | 306.48 |
| EINECS号 | 217-233-0 |
| 相关类别 | 脂肪酸甲酯;脂肪酸甲酯溶液;合成;脂肪酸;提取;Aliphatics;Fatty Acid Derivatives & Lipids;Glycerols;中药对照品 |
| Mol文件 | 1783-84-2.mol |
| 结构式 |  |
顺式-8，11，14-二十烷三烯酸甲酯 性质
| 沸点 | 200°C(lit.) |
|---|---|
| 密度 | 0.917±0.06 g/cm3(Predicted) |
| 折射率 | n |
| 闪点 | 144 °F |
| 储存条件 | -20°C |
| 溶解度 | 氯仿：50 mg/mL，澄清，无色 |
| 形态 | 液体 |
| 酸度系数(pKa) | 4.77±0.10(Predicted) |
| 颜色 | 无色至淡黄色 |
| 生物来源 | plant oil (Borage) |
| BRN | 1796533 |
| 稳定性 | 感光 |
| 化妆品成分功效 | 皮肤调理 |
| InChI | 1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12- |
| InChIKey | HOBAELRKJCKHQD-QNEBEIHSSA-N |
| SMILES | CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O |
|
Human Endogenous Metabolite
|
Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.
Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.
Dihomo-γ-linolenic acid modulates mitochondrial respiration.
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.
Western Blot Analysis
| Cell Line: | THP-1 macrophages |
| Concentration: | 50 μM (pre-treated) |
| Incubation Time: | 24 hours |
| Result: | Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727. |
Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
| Animal Model: | Female nude mice (48 four-week old) |
| Dosage: | 8 mg/mouse |
| Administration: | Oral gavage, twice a week, for 35 days |
| Result: | Suppressed metastasis potential in D5D-KD tumors. |
安全信息
| 提供商 | 语言 |
|---|---|
|
英文
|