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| | tert-Butyl 2,6-dichloroisonicotinate Basic information |
| Product Name: | tert-Butyl 2,6-dichloroisonicotinate | | Synonyms: | tert-Butyl 2,6-dichloro-4-pyridinecarboxylate;TERT-BUTYL 2,6-DICHLOROISONICOTINATE;2,6-dichloro-4-pyridinecarboxylic acid 1,1-dimethylethyl ester;2,6-Dichloroisonicotinic acid tert-butyl ester;2,6-Dichloroisonicotinic Acid t-butyl ester;tert-Butyl 2,6-Dichloroisonicotinate;tert-Butyl 2,6-Dichloropyridine-4-carboxylate;2,6-Dichloroisonicotinic Acid tert-Butyl Ester
tert-Butyl 2,6-Dichloro-4-pyridinecarboxylate
2,6-Dichloro-4-pyridinecarboxylic Acid tert-Butyl Ester | | CAS: | 75308-46-2 | | MF: | C10H11Cl2NO2 | | MW: | 248.11 | | EINECS: | | | Product Categories: | | | Mol File: | 75308-46-2.mol |  |
| | tert-Butyl 2,6-dichloroisonicotinate Chemical Properties |
| Melting point | 80.0 to 84.0 °C | | Boiling point | 326°C | | density | 1.278 | | Fp | 151°C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder to crystal | | pka | -4.43±0.10(Predicted) | | color | White to Light yellow to Light orange | | CAS DataBase Reference | 75308-46-2(CAS DataBase Reference) |
| | tert-Butyl 2,6-dichloroisonicotinate Usage And Synthesis |
| Synthesis | To a solution of 2,6-dichloroisonicotinic acid (2 g, 10.4 mmol) in toluene (50 mL) N, N- dimethylformamide di-fert-butil acetal (15 mL, 62.5 mmol) was added under nitrogen atmosphere and mixture heated at 80°C overnight. Ethyl acetate was added, and the organic layer was washed with water and brine, dried (MgS04), filtered and concentrated to yield tert-Butyl 2,6-dichloroisonicotinate (2.34 g, 87 per cent) as a solid. | | References | [1] Patent: WO2008/11499, 2008, A1. Location in patent: Page/Page column 37-38
[2] Organic Process Research and Development, 2009, vol. 13, # 6, p. 1145 - 1155
[3] Patent: WO2010/111058, 2010, A1. Location in patent: Page/Page column 79 |
| | tert-Butyl 2,6-dichloroisonicotinate Preparation Products And Raw materials |
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