2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester

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2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester manufacturers

  • SN 6
  • SN 6 pictures
  • $38.00
  • 2026-07-14
  • CAS:415697-08-4
  • Purity: 98.00%
  • Supply Ability: 10g
2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester Basic information
Product Name:2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
Synonyms:SN-6;SN-6;SN6;SN 6;4-Thiazolidinecarboxylic acid, 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-, ethyl ester;Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate;inhibit,SN 6,Na+/Ca2+ Exchanger,SN-6,Inhibitor;SN 6, 10 mM in DMSO;2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
CAS:415697-08-4
MF:C20H22N2O5S
MW:402.46
EINECS:
Product Categories:Ion transporter and other ion channel
Mol File:415697-08-4.mol
2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester Structure
2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester Chemical Properties
Boiling point 581.2±50.0 °C(Predicted)
density 1.285±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO : 62.5 mg/mL (155.29 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form Powder
pka6.63±0.60(Predicted)
color White to light yellow
InChI1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3
InChIKeyZVYIJXLMBWCGHP-UHFFFAOYSA-N
SMILESO=C(OCC)C1CSC(CC2=CC=C(OCC3=CC=C([N+]([O-])=O)C=C3)C=C2)N1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester Usage And Synthesis
UsesSN 6 is an inhibitor of Na+/Ca+ exchanger (NCX). NCX inhibitors can ameliorate cardiac ischemia-reperfusion injury and promote high-frequency fatigue of skeletal muscle. Inhibitor of bafilomycin A1-induced expression of cyclooxygenase (COX-2).
Biological ActivitySelective Na + /Ca 2+ -exchange (NCX) inhibitor; displays some selectivity for NCX1. IC 50 values are 2.9, 16 and 8.6 μ M for inhibition of intracellular Na+-dependent 45 Ca 2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC 50 = 18 μ M) but minimal activity against NCKX2 and various receptors and ion channels (IC 50 > 30 μ M). Preferentially blocks Ca 2+ influx mode and is more selective for NCX isoforms than KB-R7943 (2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate ). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC 50 = 0.63 μ M).
storageDesiccate at +4°C
2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester Preparation Products And Raw materials
Tag:2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester(415697-08-4) Related Product Information
2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester 2-Benzyl-thiazolidine-4-carboxylic acid methyl 2-{[2-(4-methoxyphenyl)ethyl]amino}acetate 1,3-Dimethyluric acid L-701,324 NBQX DISODIUM SALT