SN 6
| 中文名称 | SN 6 |
|---|---|
| 中文同义词 | 化合物SN6;2-(4-((4-硝基苄基)氧基)苄基)噻唑烷-4-羧酸乙酯;SN6,NA + / CA2 +交换抑制剂(反向模式);化合物SN6,10 MM DMSO 溶液 |
| 英文名称 | 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester |
| 英文同义词 | SN-6;SN-6;SN6;SN 6;4-Thiazolidinecarboxylic acid, 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-, ethyl ester;Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate;inhibit,SN 6,Na+/Ca2+ Exchanger,SN-6,Inhibitor;SN 6, 10 mM in DMSO;2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester |
| CAS号 | 415697-08-4 |
| 分子式 | C20H22N2O5S |
| 分子量 | 402.46 |
| EINECS号 | |
| 相关类别 | Ion transporter and other ion channel |
| Mol文件 | 415697-08-4.mol |
| 结构式 |  |
SN 6 性质
| 沸点 | 581.2±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.285±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | DMSO：62.5 mg/mL（155.29 mM；需要超声波）H2O：< 0.1 mg/mL（不溶） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 6.63±0.60(Predicted) |
| 颜色 | 白色至浅黄色 |
| InChI | 1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3 |
| InChIKey | ZVYIJXLMBWCGHP-UHFFFAOYSA-N |
| SMILES | O=C(OCC)C1CSC(CC2=CC=C(OCC3=CC=C([N+]([O-])=O)C=C3)C=C2)N1 |
| Target | Value |
|
NCX1
(Cell-free assay) | 2.9 μM |
|
NCX3
(Cell-free assay) | 8.6 μM |
|
NCX2
(Cell-free assay) | 16 μM |
SN 6 is a selective Na + /Ca 2+ exchanger inhibitor, which inhibits the initial rate of 45 Ca 2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC 50 values of 2.9 ± 0.12, 16 ± 1.1, and 8.6 ± 0.27 μM. SN 6 (up to 30 μM) also less potently inhibits muscarinic acetylcholine receptor, with a higher IC 50 of 18 μM. SN 6 (0.3-30 μM) completely inhibits the initial rate of Na + i -dependent 45 Ca 2+ uptake into Na + -loaded sarcolemmal vesicles in a dose dependent manner (IC 50 , 5.3 ± 0.37 μM). SN 6 (0.3-10 μM) dose-dependently protects against the hypoxia/reoxygenation-induced LDH release in parental LLC-PK1 cells and NCX1 transfectants but not in K229Q transfectants. SN 6 (1-30 μM) suppresses the bidirectional outward and inward I NCX in a concentration-dependent manner, with IC 50 values of 2.3 μM and 1.9 μM, respectively. SN 6 also inhibits bidirectional current (I NCX ) in a [Na + ]i concentration-dependent manner, with IC 50 values of 3.4 μM, 2.3 μM, and 1.1 μM at 10 mM, 20 mM, and 30 mM [Na + ]i, respectively. SN 6 inhibits hypoxia/reoxygenation-induced LDH release with an IC 50 value of 0.63 ± 0.15 μM in NCX1 transfectants.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-107658 | SN 6 SN 6 | 415697-08-4 | 1 mg | 288元 |
| 2026/09/15 | HY-107658 | SN 6 SN 6 | 415697-08-4 | 5mg | 720元 |