| Company Name: |
Chembest Research Laboratories Limited Gold
|
| Tel: |
+86-21-20908456 |
| Email: |
sales@BioChemBest.com |
| Products Intro: |
Product Name:RU 24969 Hemisuccinate
CAS:107008-28-6
Purity:98% Package:1g Remarks:Biochemical Reagents; Pharmaceutical Intermediates
|
| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:RU 24969 heMisuccinate;5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indoleheMisuccinate
CAS:107008-28-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
|
| | 5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE Basic information |
| Product Name: | 5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE | | Synonyms: | 5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE;RU 24969 HEMISUCCINATE;5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole succinate (2:1) salt;RU-24969;Butanedioic acid, compd. with 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:1);5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole hemisuccinate;5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate(2:1) | | CAS: | 107008-28-6 | | MF: | C18H22N2O5 | | MW: | 346.38 | | EINECS: | | | Product Categories: | Inhibitors;Serotonin receptor | | Mol File: | 107008-28-6.mol |  |
| | 5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | form | Solid | | color | Light yellow to yellow | | InChI | InChI=1S/2C14H16N2O.C4H6O4/c2*1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10;5-3(6)1-2-4(7)8/h2*2-4,8-9,15-16H,5-7H2,1H3;1-2H2,(H,5,6)(H,7,8) | | InChIKey | BNYJLRQAWCQJOM-UHFFFAOYSA-N | | SMILES | N1C2C=CC(OC)=CC=2C(C2CCNCC=2)=C1.C(O)(=O)CCC(O)=O.N1C2C=CC(OC)=CC=2C(C2CCNCC=2)=C1 |
| | 5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE Usage And Synthesis |
| Uses | RU 24969 Succinate is a SR-1A and SR-1B, and moderate SR-2C agonist. 5-HT1B/1A agonist. Also, it is a well-established substrate for human serotonin transporter (SERT). | | Biological Activity | Potent 5-HT 1A/1B and moderate 5-HT 2C agonist that may also release 5-HT. Centrally active following systemic administration. | | in vivo | RU 24969 succinate (1 and 3 mg/kg; s.c., once) potentiates addictive agent-induced effects[2].
RU 24969 succinate (0.03-3.0 mg/kg; s.c., once) dose-dependently decreases water consumption in water deprived rats[4]. | Animal Model: | Male Wistar rats with cocaine injection[2] | | Dosage: | 1 and 3 mg/kg | | Administration: | Subcutaneous injection; 1 and 3 mg/kg, once | | Result: | Increased cocaine-induced elevation of nucleus accumbens (NAcc) dopamine DA levels and reduction of ventral tegmental area (VTA) GABA levels.
|
|
| | 5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE Preparation Products And Raw materials |
|