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| | 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Basic information |
| Product Name: | 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER | | Synonyms: | 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;[1-(TERT-BUTOXYCARBONYL)AZETIDIN-2-YL]METHANOL;1-BOC-2-HYDROXYMETHYL-AZETIDINE;1-Boc-2-azetidinemethanol;N-Boc-2-azetidinemethanol;R,S-1-[(1,1-Dimethylethoxy)carbonyl]azetidine-2-methanol;1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester;1-(tert-Butoxycarbonyl)-2-azetidinemethanol | | CAS: | 174346-82-8 | | MF: | C9H17NO3 | | MW: | 187.24 | | EINECS: | | | Product Categories: | | | Mol File: | 174346-82-8.mol |  |
| | 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties |
| Boiling point | 270.3±13.0 °C(Predicted) | | density | 1.115±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 14.77±0.10(Predicted) |
| | 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Usage And Synthesis |
| Uses | [1-(tert-Butoxycarbonyl)azetidin-2-yl]methanol is used as a potential positiron emission tomography imaging agents for nicotinic acetylcholine receptors. | | Synthesis | General procedure for the synthesis of tert-butyl 2-hydroxymethyl-azetidine-1-carboxylate from N-Boc-azetidine-2-carboxylic acid: to a solution of N-Boc-azetidine-2-carboxylic acid (1.45 g, 7.21 mmol) in anhydrous THF (12 mL) was added slowly and dropwise borane-methyl sulfide complex (10 M, 3 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched with methanol (10 mL) followed by dilution of the reaction mixture with dichloromethane (100 mL). The organic phase was washed with water (40 mL x 3), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford tert-butyl 2-hydroxymethyl-azetidine-1-carboxylate (1.25 g) as a colorless oil.MS-ESI (m/z): 132.0 [M+1-56]+. | | References | [1] Patent: WO2015/7219, 2015, A1. Location in patent: Page/Page column 38 |
| | 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials |
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