| Company Name: |
Ark Pharm, Inc. |
| Tel: |
847-367-3680 |
| Email: |
sales@arkpharminc.com |
|
| | 4-Hydroxycyclohexanecarboxylic acid Basic information |
| | 4-Hydroxycyclohexanecarboxylic acid Chemical Properties |
| Melting point | 120 °C | | Boiling point | 307.9±35.0 °C(Predicted) | | density | 1.246±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | almost transparency in Methanol | | form | powder to crystal | | pka | 4.72±0.10(Predicted) | | color | White to Almost white | | InChI | InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10) | | InChIKey | HCFRWBBJISAZNK-UHFFFAOYSA-N | | SMILES | C1(C(O)=O)CCC(O)CC1 | | CAS DataBase Reference | 17419-81-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-41 | | Safety Statements | 26-36/37/39-39 | | WGK Germany | WGK 3 | | HS Code | 2918199890 | | Storage Class | 12 - Non Combustible Liquids | | Hazard Classifications | Eye Dam. 1 |
| | 4-Hydroxycyclohexanecarboxylic acid Usage And Synthesis |
| Chemical Properties | White crystal or colorless transparent viscous liquid | | Uses | 4-hydroxycyclohexanecarboxylic acid be used as organic intermediates. | | Definition | ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid. | | Synthesis | The general procedure for the synthesis of cis-4-hydroxycyclohexanecarboxylic acid from methyl cis-4-hydroxycyclohexanecarboxylate was as follows: 20 g of methyl cis-4-hydroxycyclohexanecarboxylate was dissolved in 80 mL of methanol and cooled in an ice water bath. A 5 mol/L sodium hydroxide solution of 40 mL was slowly added, and after the drop was completed, the reaction mixture was stirred at room temperature overnight. After the reaction was completed, 150 mL of water was added to dilute it. The mixture was extracted twice with ethyl acetate and the organic phase was discarded. The aqueous phase was adjusted to pH 3 with 1 mol/L HCl and extracted twice with 50 mL of ethyl acetate to combine the organic phases. The organic phase was washed twice with saturated saline in turn, dried and decolorized. After filtration, the ethyl acetate was concentrated under reduced pressure to recover the ethyl acetate, and 16 g of white solid product was obtained in 90% yield. | | IC 50 | Human Endogenous Metabolite | | References | [1] Patent: CN105061424, 2016, B. Location in patent: Paragraph 0029; 0031 |
| | 4-Hydroxycyclohexanecarboxylic acid Preparation Products And Raw materials |
|