N,N',N''-Triacetylchitotriose manufacturers
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| | N,N',N''-Triacetylchitotriose Basic information |
| Product Name: | N,N',N''-Triacetylchitotriose | | Synonyms: | Tri(N-acetylglucosaMine);GlcNAcβ(1-4)GlcNAcβ(1-4)GlcNAc;N,N',N'-TRIACETYLCHITOTRIOSE;O-[2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSYL-(1->4)]-O-[2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYR-ANOSYL-(1->4)]-2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSE;CHITOTRIOSE, TRI-N-ACETYL;GLCNAC-BETA1-4GLCNAC-BETA1-4GLCNAC;GLCNAC1-B-4GLCNAC1-B-4GLCNAC;N-acetylated Chitotriose | | CAS: | 38864-21-0 | | MF: | C24H41N3O16 | | MW: | 627.59 | | EINECS: | | | Product Categories: | Oligosaccharides | | Mol File: | 38864-21-0.mol |  |
| | N,N',N''-Triacetylchitotriose Chemical Properties |
| Melting point | 271-272°C dec. | | Boiling point | 1146.9±65.0 °C(Predicted) | | density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | H2O: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow | | pka | 12.72±0.70(Predicted) | | form | Solid | | color | White to Pale Beige | | Water Solubility | water: 50mg/mL, clear to slightly hazy, colorless to faintly yellow | | BRN | 75249 | | InChIKey | LRDDKCYRFNJZBX-KYRVBLBENA-N | | SMILES | CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](O)[C@H]1NC(C)=O)[C@H](O)CO |
| Safety Statements | 24/25 | | WGK Germany | 3 | | F | 10-21 | | HS Code | 29329990 | | Storage Class | 11 - Combustible Solids |
| | N,N',N''-Triacetylchitotriose Usage And Synthesis |
| Chemical Properties | Off-White Crystalline Solid | | Uses | N,N',N''-Triacetylchitotriose is a triose oligosaccharide derived from chitin, consisting of three N-acetylglucosamine units. It has been shown to scavenge reactive oxygen species and to protect DNA from oxidative damage. | | Uses | N,N’,N’’-Triacetyl Chitotriose is a multivalent glycosides with strong crosslinking activity for lectin as a specific coagulant. | | Definition | ChEBI: Tri-N-acetylchitotriose is a N-acyl-hexosamine. | | Reactions | The hydrolytic activity of lysozyme towards 4-methylumbelliferyl tetra-N-acetyl-β-chitotetraoside (4-MU-(GlcNAc)4) was little affected by ionic strength, though the activity of lysozyme towards cell suspension of Micrococcus lysodeikticus varied markedly with ionic strength. About 40-60percent of lysozyme activity with 4-MU-(GlcNAc)4 as a substrate was inhibited by 0.1 mM N,N',N''-triacetylchitotriose ((GlcNAc)3), but the lytic activity of lysozyme towards M. lysodeikticus was little affected. The kinetics of hydrolysis of 4-MU-(GlcNAc)4 by hen eggwhite (HEW) lysozyme and human placental (HP) lysozyme and the inhibition of this hydrolysis by (GlcNAc)3 were investigated. The K(s) values for 4-MU-(GlcNAc)4 of HEW- and HP-lysozymes were 19.7 and 27.9 μM, respectively, and the V(max) values were 0.124 and 0.0833 nmol/min/mg, respectively. The k values of both enzymes were very low, implying a poor orientation of the scissile bond in the substrate molecule with respect to the active site of lysozyme. (GlcNAc)3 inhibited lysozyme with hyperbolic mixed-type inhibition. The inhibition reduced V(max) values of both lysozymes. The K(s) value of HEW-lysozyme was increased by the addition of the inhibitory whereas the K(s) value of HP-lysozyme was decreased. The K(i) value was 29.6 μm for HEW-lysozyme and 106 μM for HP-lysozyme.
- Hydrolysis of 4-methylumbelliferyl tetra-N-acetyl-β-chitotetraoside by lysozyme and its inhibition by N,N',N''-triacetylchitotriose
- Tanimoto; Fukuda; Kawamura - Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 9, p. 3607 - 361
| | Biological Activity | N,Nμ,Nμμ-Triacetylchitotriose is a chitin oligosaccharide, th at promotes lysozyme inhibition. Chitin oligosaccharides are associated with many physiological functions. They are biodegradable and are useful in identifying chitin polysaccharides and associated glycoconjugates. |
| | N,N',N''-Triacetylchitotriose Preparation Products And Raw materials |
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