5-endo-BCN-pentanoic acid manufacturers
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| | 5-endo-BCN-pentanoic acid Basic information |
| Product Name: | 5-endo-BCN-pentanoic acid | | Synonyms: | 5-endo-BCN-pentanoic acid;endo-BCN-pentanoic acid;Pentanoic acid, 5-[[[(1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethoxy]carbonyl]amino]-, rel-;5-[[[(1α,8α,9β)-Bicyclo[6.1.0]non-4-yn-9-ylmethoxy]carbonyl]amino]pentanoic acid;endo-BCN-(5-Ava)-OH | | CAS: | 2364591-80-8 | | MF: | C16H23NO4 | | MW: | 293.36 | | EINECS: | | | Product Categories: | | | Mol File: | 2364591-80-8.mol |  |
| | 5-endo-BCN-pentanoic acid Chemical Properties |
| Boiling point | 495.2±28.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | storage temp. | Storage temp. -20°C | | solubility | Soluble in DMSO, DCM, DMF | | pka | 4.72±0.10(Predicted) | | form | Oil | | color | Colorless to light yellow |
| | 5-endo-BCN-pentanoic acid Usage And Synthesis |
| Description | endo-BCN-pentanoic acid is a click chemistry reagent containing a BCN group and a terminal carboxylic acid. The BCN group can react with azide-tagged compounds or biomolecules. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | 5-endo-BCN-pentanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 5-endo-BCN-pentanoic acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | Alkyl-Chain | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 5-endo-BCN-pentanoic acid Preparation Products And Raw materials |
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