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2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel-

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2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel- Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:HM43239
CAS:2294874-49-8
Purity:98.56% Package:1mg;64USD|5mg;155USD|10mg;238USD
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
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Products Intro: Product Name:Tuspetinib
CAS:2294874-49-8
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
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Products Intro: Product Name:Tuspetinib
CAS:2294874-49-8
Purity:98% HPLC Package:1g
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Products Intro: CAS:2294874-49-8
Purity:98% Package:1g;5g
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Products Intro: Product Name:HM43239 Tuspetinib
CAS:2294874-49-8
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2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel- manufacturers

  • HM43239
  • HM43239 pictures
  • $45.00
  • 2026-08-13
  • CAS:2294874-49-8
  • Purity: 99.70%
  • Supply Ability: 10g
2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel- Basic information
Product Name:2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel-
Synonyms:2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel-;HM43239,HM-43239;HM43239, 10 mM in DMSO;Tuspetinib (HM43239);rel-5-Chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin-1-yl)methyl)phenyl)-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine;HM43239 Tuspetinib;tuspetinib
CAS:2294874-49-8
MF:C29H33ClN6
MW:501.07
EINECS:
Product Categories:
Mol File:2294874-49-8.mol
2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel- Structure
2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel- Chemical Properties
Boiling point 693.1±65.0 °C(Predicted)
density 1.258±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 125 mg/mL (249.47 mM; Need ultrasonic)
pka14.98±0.30(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel- Usage And Synthesis
UsesTuspetinib (HM43239) is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib inhibits the proliferation and induces the apoptosis of leukemic cells[1][2][3].
in vivo

Tuspetinib shows the excellent dose proportional antitumor activity in mouse models xenografted with both MV4-11 and MOLM-13 cell lines without any significant toxicity[1].
Tuspetinib prolongs survival in FLT3 ITD/TKD double mutated xenograft mouse models[3].

IC 50FLT3 WT: 1.1 nM (IC50); FLT3 ITD: 1.8 nM (IC50); FLT3 D835Y: 1.0 nM (IC50)
References[1] Miyoung Lee, et.al. Abstract 804: Antitumor activity of the potent and novel FLT3 inhibitor HM43239 in acute myeloid leukemia. Cancer Res July 1 2018 (78) (13 Supplement) 804.
[2] Naval G. Daver, et.al. HM43239, a Novel Potent Small Molecule FLT3 Inhibitor, in Acute Myeloid Leukemia (AML) with FMS-like Tyrosine Kinase 3 (FLT3) Mutations: Phase 1 /2 Study. Blood 2019; 134 (Supplement_1): 1331.
[3] JiSook Kim, et.al. Abstract 1293: HM43239, a novel FLT3 inhibitor in overcoming resistance for acute myeloid leukemia. Cancer Res July 1 2019 (79) (13 Supplement) 1293.
2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel- Preparation Products And Raw materials
Tag:2-Pyrimidinamine, 5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-, rel-(2294874-49-8) Related Product Information
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