Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
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Products Intro:	Product Name:PF-9363 CAS:2569009-58-9 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Company Name:	Zhengzhou Alfa Chemical Co.,Ltd
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Company Name:	TargetMol Chemicals Inc.
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Products Intro:	Product Name:PF-9363 CAS:2569009-58-9 Purity:99.25% Package:1mg;67USD\|5mg;163USD\|10mg;263USD

Company Name:	Shanghai UCHEM Inc.
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Products Intro:	Product Name:PF-9363 CAS:2569009-58-9 Purity:0.98 Package:5g;1g

Company Name:	TargetMol Chemicals Inc.
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Products Intro:	Product Name:PF-9363；CTX-3648 CAS:2569009-58-9 Package:1 mg；10 mg；100 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- manufacturers

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Basic information

Product Name:	Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-
Synonyms:	Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-;CTX-3648;2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1 -ylmethyl)-1,2-benzoxazol-3-yl]benzenesulfonamide;CTx-648,cancer,patient-derived,anti-tumor,HAT,CTx648,Inhibitor,HATs,selective,xenograft,CTx 648,Histone Acetyltransferase,PF9363,inhibit,PF 9363,potent,PF-9363;N-(6-((1H-Pyrazol-1-yl)methyl)-4-methoxybenzo[d]isoxazol-3-yl)-2,6-dimethoxybenzenesulfonamide;PF-9363 (CTx-648);2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-benzenesulfonamide;PF-9363, 10 mM in DMSO
CAS:	2569009-58-9
MF:	C20H20N4O6S
MW:	444.46
EINECS:
Product Categories:
Mol File:	2569009-58-9.mol

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Chemical Properties

Boiling point	692.0±65.0 °C(Predicted)
density	1.43±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 2mg/mL, clear (Warmed)
form	Solid
pka	6.34±0.30(Predicted)
color	White to off-white
InChI	1S/C20H20N4O6S/c1-27-14-6-4-7-15(28-2)19(14)31(25,26)23-20-18-16(29-3)10-13(11-17(18)30-22-20)12-24-9-5-8-21-24/h4-11H,12H2,1-3H3,(H,22,23)
InChIKey	VNSQFPFWUAZOTQ-UHFFFAOYSA-N
SMILES	O=S(NC1=NOC2=CC(CN3N=CC=C3)=CC(OC)=C21)(C4=C(OC)C=CC=C4OC)=O

Safety Information

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

MSDS Information

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Usage And Synthesis

Uses	PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2].
Biological Activity	PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2]. PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker[1].PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1]. PF-9363 shows strong anti-tumor activity in patient-derived xenograft models[1].
in vivo	PF-9363 shows strong anti-tumor activity in patient-derived xenograft models^[1].
IC 50	MOZ/MORF
References	[1]. Shikhar S, et al. First-in-class KAT6A/KAT6B Inhibitor CTx-648 (PF-9363) Demonstrates Potent Anti-tumor Activity in ER+ Breast Cancer with KAT6A Dysregulation [2]. WO2020254946

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Preparation Products And Raw materials

Tag:Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-(2569009-58-9) Related Product Information

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