| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
PRL-3 INHIBITOR I manufacturers
- PRL-3 Inhibitor I
-
- $31.00
-
2026-07-27
- CAS:893449-38-2
- Purity: 98.11%
- Supply Ability: 10g
|
| | PRL-3 INHIBITOR I Basic information |
| Product Name: | PRL-3 INHIBITOR I | | Synonyms: | PRL-3 INHIBITOR I;Phosphatase of regenerating liver-3, Inhibitor I, 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone;5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone;Phosphatase of regenerating liver-3, Inhibitor I;PRL-3 Inhibitor;PRL-3 Inhibitor - CAS 893449-38-2 - Calbiochem;5-(5-Bromo-2-((2-bromobenzyl)oxy)benzylidene)-2-thioxothiazolidin-4-one;P0180 | | CAS: | 893449-38-2 | | MF: | C17H11Br2NO2S2 | | MW: | 485.21 | | EINECS: | | | Product Categories: | | | Mol File: | 893449-38-2.mol |  |
| | PRL-3 INHIBITOR I Chemical Properties |
| density | 1.85±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: >10mg/mL | | form | Yellow solid | | pka | 7.11±0.50(Predicted) | | color | yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | | InChI | 1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+ | | InChIKey | HXNBAOLVPAWYLT-OVCLIPMQSA-N | | SMILES | Brc1ccc(OCc2ccccc2Br)c(c1)\C=C3\SC(=S)NC3=O |
| | PRL-3 INHIBITOR I Usage And Synthesis |
| Description | P0108 (893449-38-2) is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 μM.1 Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.2 Sensitizes PRL-3-expressing cancer cells to chemotherapeutics.3 Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells.4 | | Uses | 5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone is a a cell-permeable benzylidene rhodamine that inhibits Phosphatase of regenerating liver 3 (PRL-3). | | Definition | ChEBI: 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one is an aromatic ether. | | in vitro | prl-3 inhibitor, in a dose-dependent fashion, blocked the dephosphorylation of difmup by prl-3 and strongly suppressed the activity of prl-3 phosphatase in prl-3 overexpressing dld-1 colon tumor cells [dld-1 (prl-3)]. also, prl-3 inhibitor dose-dependently blocked the migration of dld-1 (prl-3) cells, however, it did not inhibit the proliferation of dld-1(prl-3) cells, suggesting that prl-3 inhibitor significantly blocked cell immigration and invasion without cytotoxicity [1]. | | IC 50 | 900 nm: blocks human phosphatase of regenerating liver 3 (prl-3) in vitro. | | References | [1] JOONG-KWON CHOI et al. et al. Synthesis and Biological Evaluation of Rhodanine Derivatives as PRL-3 Inhibitors.[J]. ChemInform, 2006, 37 34. DOI:10.1002/chin.200634126
[2] GARAM MIN . Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 13: Pages 3769-3774. DOI:10.1016/j.bmcl.2013.04.092
[3] JIANBIAO ZHOU. PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy.[J]. PLoS ONE, 2011: e19798. DOI:10.1371/journal.pone.0019798
[4] WEI TIAN. Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783.[J]. BMC Biochemistry, 2012, 13: 22. DOI:10.1186/1471-2091-13-22 |
| | PRL-3 INHIBITOR I Preparation Products And Raw materials |
|