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| | 2-Amino-thiazole-4-carboxylamide Basic information |
| Product Name: | 2-Amino-thiazole-4-carboxylamide | | Synonyms: | 2-aminothiazole-4-carboxamide;4-Thiazolecarboxamide,2-amino-(9CI);2-AMINOTHIAZOLE-4-CARBOXAMIDE,PURITY:97% MIN(HPLC);2-amino-1,3-thiazole-4-carboxamide;2-Amino-1,3-thiazole-4-carboamide;2-Amino-4-thiazolecarboxamide;4-Thiazolecarboxamide, 2-amino-;2-Aminothiazole-4-carboxamide (~15% Inorganics) | | CAS: | 118452-02-1 | | MF: | C4H5N3OS | | MW: | 143.17 | | EINECS: | | | Product Categories: | pyridine;Heterocyclic Compounds;AMIDE | | Mol File: | 118452-02-1.mol |  |
| | 2-Amino-thiazole-4-carboxylamide Chemical Properties |
| Melting point | >195°C (dec.) | | Boiling point | 460.3±18.0 °C(Predicted) | | density | 1.537±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) | | form | Solid | | pka | 15.14±0.50(Predicted) | | color | Pale Beige |
| | 2-Amino-thiazole-4-carboxylamide Usage And Synthesis |
| Uses | 2-Aminothiazole-4-carboxamide is a useful intermediate for organic synthesis and other chemical processes. | | Synthesis | General procedure for the synthesis of 2-aminothiazole-4-carboxylic acid from ethyl 2-aminothiazole-4-carboxylate: 3.0 g of ethyl 2-aminothiazole-4-carboxylate was dissolved in 100 mL of ammonia, and the reaction was stirred for 2 hours at room temperature. Upon completion of the reaction, the reaction solution was concentrated to dryness and left to precipitate needle-like crystals. The crystals were collected by filtration and washed several times with cold water to remove impurities. Finally, the product was dried at room temperature to give 1.9 g of 2-aminothiazole-4-carboxamide in 76% yield with a melting point of 208-211 °C. | | References | [1] Patent: EP2039686, 2009, A1. Location in patent: Page/Page column 23
[2] Patent: US2010/87448, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: US2006/63814, 2006, A1. Location in patent: Page/Page column 62 |
| | 2-Amino-thiazole-4-carboxylamide Preparation Products And Raw materials |
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