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| | Ethyl 3-aminopropanoate hydrochloride Basic information |
| | Ethyl 3-aminopropanoate hydrochloride Chemical Properties |
| Melting point | 67-70 °C(lit.) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Crystalline Powder | | color | White to off-white | | Water Solubility | almost transparency | | Sensitive | Hygroscopic | | BRN | 3559095 | | Major Application | peptide synthesis | | InChI | InChI=1S/C5H11NO2.ClH/c1-2-8-5(7)3-4-6;/h2-4,6H2,1H3;1H | | InChIKey | RJCGNNHKSNIUAT-UHFFFAOYSA-N | | SMILES | C(=O)(OCC)CCN.Cl | | CAS DataBase Reference | 4244-84-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 36/37/39-26-22-36-24/25 | | WGK Germany | 3 | | HazardClass | HYGROSCOPIC | | HS Code | 29224995 | | Storage Class | 11 - Combustible Solids |
| | Ethyl 3-aminopropanoate hydrochloride Usage And Synthesis |
| Chemical Properties | White to off-white crystalline powder | | Uses | peptide synthesis | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | Freshly distilled thionyl chloride (250 mL) was slowly added dropwise to stirred anhydrous ethanol (400 mL) at -10 °C. After maintaining the reaction at -10 °C for 20 min, β-alanine (82.56 g, 0.93 mol) was slowly added to the thionyl chloride/ethanol mixture. The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the excess thionyl chloride was removed by distillation and the reaction solution was concentrated to half of the original volume under reduced pressure. The white precipitate precipitated from the concentrate was collected by filtration and washed with cold ether to give a final white crystalline powder of β-alanine ethyl ester hydrochloride (124.34 g, 87% yield). | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 19, p. 6200 - 6204
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 6, p. 2336 - 2350
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 11 - 20
[4] Journal of Heterocyclic Chemistry, 2013, vol. 50, # 5, p. 1067 - 1070
[5] Russian Chemical Bulletin, 2017, vol. 66, # 1, p. 136 - 142 |
| | Ethyl 3-aminopropanoate hydrochloride Preparation Products And Raw materials |
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