4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid

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4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid manufacturers

  • CD2665
  • CD2665 pictures
  • $40.00
  • 2026-05-11
  • CAS:170355-78-9
  • Purity: 99.71%
  • Supply Ability: 10g
  • CD2665
  • CD2665 pictures
  • $40.00
  • 2026-04-20
  • CAS:170355-78-9
  • Purity: 99.71%
  • Supply Ability: 10g
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Basic information
Product Name:4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid
Synonyms:4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid;4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoicacid;CD 2665;4-[7-(1-ADAMANTYL)-6-(2-METHOXYETHOXYMETHOXY)NAPHTHALEN-3-YL]BENZOIC ACID;Benzoic acid, 4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-;4-(7-((3r,5r,7r)-adamantan-1-yl)-6-((2-methoxyethoxy)methoxy)naphthalen-2-yl)benzoic acid;CD2665,CD-2665;CD2665, 10 mM in DMSO
CAS:170355-78-9
MF:C31H34O5
MW:486.6
EINECS:
Product Categories:
Mol File:170355-78-9.mol
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Structure
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Chemical Properties
Boiling point 668.6±55.0 °C(Predicted)
density 1.227±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml
form A crystalline solid
pka4.13±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Usage And Synthesis
UsesCD 2665 is a selective RARβ/γ antagonist.
Biological ActivitySelective RAR β / γ antagonist (K D values are 110, 306 and > 1000 nM for RAR γ , RAR β and RAR α respectively). Blocks retinoic acid-induced apoptosis ex vivo .
in vivo

CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice[2].
CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion[3].

Animal Model:Mice submitted to 10 months of ethanol consumption[2].
Dosage:0.6 mg/kg
Administration:Subcutaneous injection; daily, for 22 days.
Result:Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.
Animal Model:Male and female mice (3 weeks)[3].
Dosage:1.6 mg/kg
Administration:Oral gavage/intragastric; daily, for 31 days.
Result:Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only.
storageStore at +4°C
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Preparation Products And Raw materials
Tag:4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid(170355-78-9) Related Product Information
Hydroxy Adapalene 2-Naphthalenecarboxylicacid, 6-[4-methoxy-3-(1-methylcyclohexyl)phenyl]- 4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Adapalene CD1530 3-(1-adamantyl)-4-methoxybenzoic acid