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| | 2-Chloromethylbenzimidazole Basic information |
| | 2-Chloromethylbenzimidazole Chemical Properties |
| Melting point | 146-148 °C (dec.)(lit.) | | Boiling point | 274.83°C (rough estimate) | | density | 1.2387 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Storage temp. -20°C | | pka | 11.18±0.10(Predicted) | | form | Powder | | color | Beige to dark yellow | | Water Solubility | Insoluble in water. | | InChI | InChI=1S/C8H7ClN2/c9-5-8-10-6-3-1-2-4-7(6)11-8/h1-4H,5H2,(H,10,11) | | InChIKey | SPMLMLQATWNZEE-UHFFFAOYSA-N | | SMILES | C1(CCl)NC2=CC=CC=C2N=1 | | CAS DataBase Reference | 4857-04-9(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Chloromethylbenzimidazole Usage And Synthesis |
| Chemical Properties | beige to dark yellow powder | | Uses | 2-(Chloromethyl)benzimidazole is used as intermediate in pharmaceutical , in organic synthesis . | | Synthesis | GENERAL METHOD: A mixture of o-phenylenediamine (0.1 mol) and chloroacetic acid (0.15 mol) in 100 mL of 5N HCl was heated to reflux and stirred continuously for 3-5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently neutralized with sodium bicarbonate solution. The precipitate of 2-chloromethylbenzimidazole formed was collected by filtration, washed several times with water and finally dried to obtain the pure product. | | References | [1] Collection of Czechoslovak Chemical Communications, 1991, vol. 56, # 6, p. 1358 - 1360
[2] Revue Roumaine de Chimie, 2016, vol. 61, # 1, p. 15 - 22
[3] Oriental Journal of Chemistry, 2017, vol. 33, # 6, p. 3138 - 3143
[4] Heterocycles, 2002, vol. 57, # 8, p. 1423 - 1432
[5] Journal of the Korean Chemical Society, 2010, vol. 54, # 5, p. 589 - 593 |
| | 2-Chloromethylbenzimidazole Preparation Products And Raw materials |
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