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| | 2-Guanidinobenzimidazole Basic information |
| | 2-Guanidinobenzimidazole Chemical Properties |
| Melting point | 242-244 °C (dec.) (lit.) | | Boiling point | 296.48°C (rough estimate) | | density | 1.2954 (rough estimate) | | refractive index | 1.6900 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming) | | pka | 13.67±0.30(Predicted) | | form | solid | | color | Beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. | | InChI | 1S/C8H9N5/c9-7(10)13-8-11-5-3-1-2-4-6(5)12-8/h1-4H,(H5,9,10,11,12,13) | | InChIKey | JJWCTKUQWXYIIU-UHFFFAOYSA-N | | SMILES | NC(=N)Nc1nc2ccccc2[nH]1 | | CAS DataBase Reference | 5418-95-1(CAS DataBase Reference) | | EPA Substance Registry System | Guanidine, 1H-benzimidazol-2-yl- (5418-95-1) |
| WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids |
| | 2-Guanidinobenzimidazole Usage And Synthesis |
| Description | 2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).12GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3 Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4 | | Chemical Properties | BROWN-PURPLE FINE CRYSTALLINE POWDER | | Uses | N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics. | | Definition | ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole. | | References | [1] LIANG HONG. Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling.[J]. Scientific Reports, 2015: 14077. DOI:10.1038/srep14077
[2] LIANG HONG Francesco T Iris H Kim. Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014: 9971-9976. DOI:10.1073/pnas.1324012111
[3] ELEONORA GIANTI. On the role of water density fluctuations in the inhibition of a proton channel.[J]. Journal of Family Violence, 2016, 3 1: E8359-E8368. DOI:10.1073/pnas.1609964114
[4] AMAURY PUPO Carlos G L. In pursuit of an inhibitory drug for the proton channel.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014: 9673-9674. DOI:10.1073/pnas.1408808111 |
| | 2-Guanidinobenzimidazole Preparation Products And Raw materials |
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