3-Chloro-4-hydroxy-5-nitropyridine manufacturers
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| | 3-Chloro-4-hydroxy-5-nitropyridine Basic information |
| Product Name: | 3-Chloro-4-hydroxy-5-nitropyridine | | Synonyms: | 3-Chloro-4-hydroxy-5-nitropyridine;3-Chloro-5-nitro-4-pyridinol;5-Chloro-3-nitro-4-pyridinol;4-Pyridinol, 3-chloro-5-nitro-;3-chloro-5-nitro-1H-pyridin-4-one;3-Chloro-4-hydroxy-5-nitropyridine ISO 9001：2015 REACH | | CAS: | 31872-64-7 | | MF: | C5H3ClN2O3 | | MW: | 174.54 | | EINECS: | | | Product Categories: | | | Mol File: | 31872-64-7.mol |  |
| | 3-Chloro-4-hydroxy-5-nitropyridine Chemical Properties |
| Melting point | 263℃ | | Boiling point | 339.3±37.0 °C(Predicted) | | density | 1.664±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | -1.56±0.38(Predicted) | | Appearance | White to off-white Solid |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | HS Code | 2933399990 |
| | 3-Chloro-4-hydroxy-5-nitropyridine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-chloro-4-hydroxy-5-nitropyridine from 4-hydroxy-3-nitropyridine: 3-nitropyridin-4-ol (8-a, 20 g, 142.76 mmol, 1 eq.) was dissolved in 50% aqueous acetic acid (250 mL) and reacted with the passage of chlorine gas for 20 h at room temperature. After completion of the reaction, the precipitate was collected by filtration and washed with distilled water. Intermediate 9-b (24 g, 97% yield) was finally obtained. | | References | [1] Patent: WO2013/186332, 2013, A1. Location in patent: Page/Page column 51
[2] Patent: WO2013/186335, 2013, A1. Location in patent: Page/Page column 76
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 17, p. 5352 - 5362
[4] Patent: WO2009/108551, 2009, A2. Location in patent: Page/Page column 65-66 |
| | 3-Chloro-4-hydroxy-5-nitropyridine Preparation Products And Raw materials |
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